Developmental dynamics of mitochondrial mRNA abundance and editing reveal roles for temperature and the differentiation-repressive kinase RDK1 in cytochrome oxidase subunit II mRNA editing

Developmental dynamics of mitochondrial mRNA abundance and editing reveal roles for temperature and the differentiation-repressive kinase RDK1 in cytochrome oxidase subunit II mRNA editing

ABSTRACT Developmental regulation of mitochondrial uridine insertion/deletion editing in Trypanosoma brucei is necessary to modulate parasite metabolism as it shifts from dependence on glycolysis for ATP production in the mammalian bloodstream form (BSF) to oxidative phosphorylation in the insect pr...

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Bibliographic Details
Main Authors: Joseph T. Smith, Brianna Tylec, Arunasalam Naguleswaran, Isabel Roditi, Laurie K. Read
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Trypanosoma brucei
RNA editing
differentiation
developmental regulation
Online Access:https://journals.asm.org/doi/10.1128/mbio.01854-23

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