Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-XL dual inhibitor that induces Bax-dependent apoptosis

Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-XL dual inhibitor that induces Bax-dependent apoptosis

New treatment options, such as targeted therapies, are urgently needed for the treatment of colorectal cancer (CRC), the third leading cause of cancer-related deaths worldwide. The current study focuses on demonstrating the therapeutic efficacies of APG-1252-M1 (an active form of the prodrug, APG-12...

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Bibliographic Details
Main Authors: Weilong Yao, Longchuan Bai, Shaomeng Wang, Yifan Zhai, Shi-Yong Sun
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Bcl-2
Bcl-XL, APG-1252-M1 (APG-1252)
Mcl-1 apoptosis
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000252

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