Modeling of single-particle translocation through a low-aspect-ratio nanopore
A theoretical model for the motion of tiny spherical particles in a nanopore device is developed. The nanopore has a low aspect ratio, and the particles have a radius slightly smaller than that of the nanopore. The translocation of the particle through the nanopore is driven by the difference in ext...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Japan Society of Mechanical Engineers
2019-02-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/14/1/14_18-00539/_pdf/-char/en |
| _version_ | 1811224761104072704 |
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| author | Tetsuro TSUJI Kentaro DOI Satoyuki KAWANO |
| author_facet | Tetsuro TSUJI Kentaro DOI Satoyuki KAWANO |
| author_sort | Tetsuro TSUJI |
| collection | DOAJ |
| description | A theoretical model for the motion of tiny spherical particles in a nanopore device is developed. The nanopore has a low aspect ratio, and the particles have a radius slightly smaller than that of the nanopore. The translocation of the particle through the nanopore is driven by the difference in external electric potential between the entrance and the exit of the nanopore. The model includes the effects of electrophoresis, electroosmotic flow in the nanopore, and the repulsive potential of the nanopore wall. Using this model, the time-dependent velocity of the particles during translocation through the nanopore is calculated for various parameters, such as the particle radius, the nanopore height, and the surface charge density of the particle. The motion of the particles predicted by the present model qualitatively explains the important characteristics of temporal ionic current responses across the nanopore observed in previous experimental results. |
| first_indexed | 2024-04-12T08:54:32Z |
| format | Article |
| id | doaj.art-01f7f6d690464029a2b619b09a552b2e |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-04-12T08:54:32Z |
| publishDate | 2019-02-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-01f7f6d690464029a2b619b09a552b2e2022-12-22T03:39:25ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632019-02-0114118-0053918-0053910.1299/jbse.18-00539jbseModeling of single-particle translocation through a low-aspect-ratio nanoporeTetsuro TSUJI0Kentaro DOI1Satoyuki KAWANO2Graduate School of Engineering Science, Osaka UniversityGraduate School of Engineering Science, Osaka UniversityGraduate School of Engineering Science, Osaka UniversityA theoretical model for the motion of tiny spherical particles in a nanopore device is developed. The nanopore has a low aspect ratio, and the particles have a radius slightly smaller than that of the nanopore. The translocation of the particle through the nanopore is driven by the difference in external electric potential between the entrance and the exit of the nanopore. The model includes the effects of electrophoresis, electroosmotic flow in the nanopore, and the repulsive potential of the nanopore wall. Using this model, the time-dependent velocity of the particles during translocation through the nanopore is calculated for various parameters, such as the particle radius, the nanopore height, and the surface charge density of the particle. The motion of the particles predicted by the present model qualitatively explains the important characteristics of temporal ionic current responses across the nanopore observed in previous experimental results.https://www.jstage.jst.go.jp/article/jbse/14/1/14_18-00539/_pdf/-char/ennanofluidicsnanoporecoulter counterionic currentparticle identificationelectrophoresis |
| spellingShingle | Tetsuro TSUJI Kentaro DOI Satoyuki KAWANO Modeling of single-particle translocation through a low-aspect-ratio nanopore Journal of Biomechanical Science and Engineering nanofluidics nanopore coulter counter ionic current particle identification electrophoresis |
| title | Modeling of single-particle translocation through a low-aspect-ratio nanopore |
| title_full | Modeling of single-particle translocation through a low-aspect-ratio nanopore |
| title_fullStr | Modeling of single-particle translocation through a low-aspect-ratio nanopore |
| title_full_unstemmed | Modeling of single-particle translocation through a low-aspect-ratio nanopore |
| title_short | Modeling of single-particle translocation through a low-aspect-ratio nanopore |
| title_sort | modeling of single particle translocation through a low aspect ratio nanopore |
| topic | nanofluidics nanopore coulter counter ionic current particle identification electrophoresis |
| url | https://www.jstage.jst.go.jp/article/jbse/14/1/14_18-00539/_pdf/-char/en |
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