Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or for...
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MDPI AG
2021-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/4068 |
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| author | Cheng Chi Yali Fan Cheng Li Yu Li Shan Guo Tianhe Li Nicholas Buys Vicki L. Clifton Paul B. Colditz Chenghong Yin Jing Sun |
| author_facet | Cheng Chi Yali Fan Cheng Li Yu Li Shan Guo Tianhe Li Nicholas Buys Vicki L. Clifton Paul B. Colditz Chenghong Yin Jing Sun |
| author_sort | Cheng Chi |
| collection | DOAJ |
| description | Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both <i>p</i> < 0.01) but showed no difference at week 12. The beta diversity of the three groups showed a trend towards similarity at the first two stages (<i>p</i> < 0.001 and <i>p</i> = 0.009, respectively) and finally showed no difference at week 12. Canonical redundancy analysis showed that feeding type could explain the difference in gut microbiota composition at week one and six (both <i>p</i> < 0.01). At genus level, <i>Bifidobacterium</i> was enriched in the PF group, while the <i>Enterococcus</i> and <i>Streptococcus</i> was enriched in the NPF group. In summary, formula with probiotics feeding after birth can affect gut microbiota colonisation and lead to a bacterial community with less potential pathogens. |
| first_indexed | 2024-03-10T05:10:31Z |
| format | Article |
| id | doaj.art-01f878ac792b4d0e9f0ea98982764922 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:10:31Z |
| publishDate | 2021-11-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-01f878ac792b4d0e9f0ea989827649222023-11-23T00:50:09ZengMDPI AGNutrients2072-66432021-11-011311406810.3390/nu13114068Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort StudyCheng Chi0Yali Fan1Cheng Li2Yu Li3Shan Guo4Tianhe Li5Nicholas Buys6Vicki L. Clifton7Paul B. Colditz8Chenghong Yin9Jing Sun10Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaSchool of Nursing, Jining Medical University, Jining 272067, ChinaSchool of Nursing, Weifang Medical University, Weifang 261042, ChinaBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaMenzies Health Institute Queensland, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4215, AustraliaFaculty of Medicine, Mater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD 4072, AustraliaPerinatal Research Centre, UQCCR, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, AustraliaBeijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, ChinaMenzies Health Institute Queensland, School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4215, AustraliaPremature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both <i>p</i> < 0.01) but showed no difference at week 12. The beta diversity of the three groups showed a trend towards similarity at the first two stages (<i>p</i> < 0.001 and <i>p</i> = 0.009, respectively) and finally showed no difference at week 12. Canonical redundancy analysis showed that feeding type could explain the difference in gut microbiota composition at week one and six (both <i>p</i> < 0.01). At genus level, <i>Bifidobacterium</i> was enriched in the PF group, while the <i>Enterococcus</i> and <i>Streptococcus</i> was enriched in the NPF group. In summary, formula with probiotics feeding after birth can affect gut microbiota colonisation and lead to a bacterial community with less potential pathogens.https://www.mdpi.com/2072-6643/13/11/4068microbiotaprobioticspreterm infants |
| spellingShingle | Cheng Chi Yali Fan Cheng Li Yu Li Shan Guo Tianhe Li Nicholas Buys Vicki L. Clifton Paul B. Colditz Chenghong Yin Jing Sun Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study Nutrients microbiota probiotics preterm infants |
| title | Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study |
| title_full | Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study |
| title_fullStr | Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study |
| title_full_unstemmed | Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study |
| title_short | Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study |
| title_sort | early gut microbiota colonisation of premature infants fed with breastmilk or formula with or without probiotics a cohort study |
| topic | microbiota probiotics preterm infants |
| url | https://www.mdpi.com/2072-6643/13/11/4068 |
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