A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic
The outbreak of opportunistic fungal infections such as mucormycosis has been a critical issue following coronavirus disease 19 (COVID-19). Mucormycosis is happened by the fungal group Mucorales and commonly affects immunocompromised patients. To date, COVID-19-associated mucormycosis (CAM) is bein...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Research Center for Rational Use of Drugs (RCRUD)
2023-09-01
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| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/600 |
| _version_ | 1827792691211010048 |
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| author | Hedyieh Karbasforooshan Batool Zarei Mahdi Jannati Ghazaleh Elahabadi Sepideh Elyasi Ali Akbar Heydari |
| author_facet | Hedyieh Karbasforooshan Batool Zarei Mahdi Jannati Ghazaleh Elahabadi Sepideh Elyasi Ali Akbar Heydari |
| author_sort | Hedyieh Karbasforooshan |
| collection | DOAJ |
| description |
The outbreak of opportunistic fungal infections such as mucormycosis has been a critical issue following coronavirus disease 19 (COVID-19). Mucormycosis is happened by the fungal group Mucorales and commonly affects immunocompromised patients. To date, COVID-19-associated mucormycosis (CAM) is being reported in several countries. It should be noted that CAM has been started in patients approximately within two to three weeks after the onset of COVID-19. However, here, in one case, fungal symptoms appeared after just one week. In patients with mucormycosis due to this enigmatic infection, the sinuses were most commonly affected, followed by the orbit, nose, and finally the brain. All cases received glucocorticoids as a part of viral therapy. Diabetes mellitus (DM) was reported in all but one case in which COVID-19 was detected, without complications, and this may be the sole predisposing agent. Therefore, in this manuscript, we reported eight cases of COVID-19-induced mucormycosis. Although one case experienced evacuation of the right eye, others discharge with promising outcomes after receiving surgical debridement and proper anti-fungal treatment including, amphotericin B, caspofungin, and posaconazole.
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| first_indexed | 2024-03-11T18:05:42Z |
| format | Article |
| id | doaj.art-01f88a8e33204b58ab015704859e4c29 |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-03-11T18:05:42Z |
| publishDate | 2023-09-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-01f88a8e33204b58ab015704859e4c292023-10-17T05:30:36ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092023-09-01113A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –PandemicHedyieh Karbasforooshan0Batool Zarei1Mahdi Jannati2Ghazaleh Elahabadi3Sepideh Elyasi4Ali Akbar Heydari5Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Infectious Disease, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. The outbreak of opportunistic fungal infections such as mucormycosis has been a critical issue following coronavirus disease 19 (COVID-19). Mucormycosis is happened by the fungal group Mucorales and commonly affects immunocompromised patients. To date, COVID-19-associated mucormycosis (CAM) is being reported in several countries. It should be noted that CAM has been started in patients approximately within two to three weeks after the onset of COVID-19. However, here, in one case, fungal symptoms appeared after just one week. In patients with mucormycosis due to this enigmatic infection, the sinuses were most commonly affected, followed by the orbit, nose, and finally the brain. All cases received glucocorticoids as a part of viral therapy. Diabetes mellitus (DM) was reported in all but one case in which COVID-19 was detected, without complications, and this may be the sole predisposing agent. Therefore, in this manuscript, we reported eight cases of COVID-19-induced mucormycosis. Although one case experienced evacuation of the right eye, others discharge with promising outcomes after receiving surgical debridement and proper anti-fungal treatment including, amphotericin B, caspofungin, and posaconazole. https://jpc.tums.ac.ir/index.php/jpc/article/view/600COVID-19; Fugal Infection; Mucormycosis |
| spellingShingle | Hedyieh Karbasforooshan Batool Zarei Mahdi Jannati Ghazaleh Elahabadi Sepideh Elyasi Ali Akbar Heydari A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic Journal of Pharmaceutical Care COVID-19; Fugal Infection; Mucormycosis |
| title | A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic |
| title_full | A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic |
| title_fullStr | A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic |
| title_full_unstemmed | A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic |
| title_short | A Case Series of Eight Mucormycosis Patients during SARS-CoV-2 –Pandemic |
| title_sort | case series of eight mucormycosis patients during sars cov 2 pandemic |
| topic | COVID-19; Fugal Infection; Mucormycosis |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/600 |
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