Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer
Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H2S...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/4/582 |
| _version_ | 1829139054952710144 |
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| author | John I. Toohey |
| author_facet | John I. Toohey |
| author_sort | John I. Toohey |
| collection | DOAJ |
| description | Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H2S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B12-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H2S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B12 or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease. |
| first_indexed | 2024-12-14T19:29:48Z |
| format | Article |
| id | doaj.art-01f96d9438b44257a095c8b0eebc54b8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T19:29:48Z |
| publishDate | 2017-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-01f96d9438b44257a095c8b0eebc54b82022-12-21T22:50:05ZengMDPI AGMolecules1420-30492017-04-0122458210.3390/molecules22040582molecules22040582Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group TransferJohn I. Toohey0Cytoregulation Research, Elgin, ON K0G1E0, CanadaEvidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H2S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenosylmethionine methyl transfer (RSMT), and methionine synthase (MS). Then, new reaction mechanisms for B12-dependent methyl group transfer are proposed; the mechanisms are facile and overcome difficulties that existed in previously-accepted mechanisms. Finally, the theory is applied to the effect of S°/H2S in nerve tissue involving the “hypomethylation theory” that was proposed 50 years ago to explain the neuropathology resulting from deficiency of vitamin B12 or folic acid. The conclusions are consistent with emerging evidence that sulfane sulfur/hydrogen sulfide may be beneficial in treating Alzheimer’s disease.http://www.mdpi.com/1420-3049/22/4/582sulfane sulfurhydrogen sulfidemethylationradical S-adenosylmethionine methyl transferasesmethionine synthasecobalaminviscose dialysis tubingmethionine auxotrophyhypomethylationdementiaAlzheimer’s disease |
| spellingShingle | John I. Toohey Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer Molecules sulfane sulfur hydrogen sulfide methylation radical S-adenosylmethionine methyl transferases methionine synthase cobalamin viscose dialysis tubing methionine auxotrophy hypomethylation dementia Alzheimer’s disease |
| title | Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer |
| title_full | Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer |
| title_fullStr | Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer |
| title_full_unstemmed | Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer |
| title_short | Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer |
| title_sort | possible involvement of hydrosulfide in b12 dependent methyl group transfer |
| topic | sulfane sulfur hydrogen sulfide methylation radical S-adenosylmethionine methyl transferases methionine synthase cobalamin viscose dialysis tubing methionine auxotrophy hypomethylation dementia Alzheimer’s disease |
| url | http://www.mdpi.com/1420-3049/22/4/582 |
| work_keys_str_mv | AT johnitoohey possibleinvolvementofhydrosulfideinb12dependentmethylgrouptransfer |