Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach
Glycoprotein IIb/IIIa inhibitors are an adjuvant therapy for the treatment of patients with acute coronary syndromes. The main adverse reactions are bleeding and thrombocytopenia in 1–2% of cases. A 66-year-old woman arrived at the emergency department with ST-elevation MI. The catheterisation lab w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2023-04-01
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| Series: | Interventional Cardiology: Reviews, Research, Resources |
| Online Access: | https://www.icrjournal.com/articleindex/icr.2022.23 |
| _version_ | 1797199956059095040 |
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| author | Gian-Manuel Jiménez-Rodríguez Patricia Carmona-Levario José-Alberto Ayón-Martínez Aleksandra Gasecka Luis Eduardo Juárez-Orozco Antonio Reyes-Ortega Patricia Espinosa-González Gyna Alejandra Altamirano-Solorzano Guering Eid-Lidt |
| author_facet | Gian-Manuel Jiménez-Rodríguez Patricia Carmona-Levario José-Alberto Ayón-Martínez Aleksandra Gasecka Luis Eduardo Juárez-Orozco Antonio Reyes-Ortega Patricia Espinosa-González Gyna Alejandra Altamirano-Solorzano Guering Eid-Lidt |
| author_sort | Gian-Manuel Jiménez-Rodríguez |
| collection | DOAJ |
| description | Glycoprotein IIb/IIIa inhibitors are an adjuvant therapy for the treatment of patients with acute coronary syndromes. The main adverse reactions are bleeding and thrombocytopenia in 1–2% of cases. A 66-year-old woman arrived at the emergency department with ST-elevation MI. The catheterisation lab was busy, so she received thrombolytic therapy. Coronary angiography revealed a 90% stenosis in the middle segment of the left anterior descending artery and Thrombolysis in MI 2 flow. Subsequent percutaneous coronary intervention showed abundant thrombus and a coronary dissection and it was necessary to insert five drug-eluting stents. Non-fractionated heparin and a tirofiban infusion were used. After the percutaneous coronary intervention, she developed severe thrombocytopenia, haematuria and gingivorrhagia, for which infusion of tirofiban was suspended. In follow-up, no major bleeding or subsequent haemorrhagic complications were identified. It is crucial to distinguish between heparin-induced thrombocytopenia and thrombocytopenia caused by other drugs. A high level of suspicion should be employed in these cases. |
| first_indexed | 2024-03-07T17:39:33Z |
| format | Article |
| id | doaj.art-01fbc15204594f9f9bfa076a1ac496d2 |
| institution | Directory Open Access Journal |
| issn | 1756-1477 1756-1485 |
| language | English |
| last_indexed | 2024-04-24T07:23:59Z |
| publishDate | 2023-04-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Interventional Cardiology: Reviews, Research, Resources |
| spelling | doaj.art-01fbc15204594f9f9bfa076a1ac496d22024-04-20T16:03:21ZengRadcliffe Medical MediaInterventional Cardiology: Reviews, Research, Resources1756-14771756-14852023-04-011810.15420/icr.2022.23Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series ApproachGian-Manuel Jiménez-Rodríguez0Patricia Carmona-Levario1José-Alberto Ayón-Martínez2Aleksandra Gasecka3Luis Eduardo Juárez-Orozco4Antonio Reyes-Ortega5Patricia Espinosa-González6Gyna Alejandra Altamirano-Solorzano7Guering Eid-Lidt8Interventional Cardiology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoInterventional Cardiology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoInterventional Cardiology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoDepartment of Cardiology of the Medical University of Warsaw, Warsaw, PolandCardiology Department, University Medical Center Utrecht, Utrecht, the NetherlandsCardiology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoCardiology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoHaematology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoHaematology Department, National Institute of Cardiology Ignacio Chávez, Mexico City, MexicoGlycoprotein IIb/IIIa inhibitors are an adjuvant therapy for the treatment of patients with acute coronary syndromes. The main adverse reactions are bleeding and thrombocytopenia in 1–2% of cases. A 66-year-old woman arrived at the emergency department with ST-elevation MI. The catheterisation lab was busy, so she received thrombolytic therapy. Coronary angiography revealed a 90% stenosis in the middle segment of the left anterior descending artery and Thrombolysis in MI 2 flow. Subsequent percutaneous coronary intervention showed abundant thrombus and a coronary dissection and it was necessary to insert five drug-eluting stents. Non-fractionated heparin and a tirofiban infusion were used. After the percutaneous coronary intervention, she developed severe thrombocytopenia, haematuria and gingivorrhagia, for which infusion of tirofiban was suspended. In follow-up, no major bleeding or subsequent haemorrhagic complications were identified. It is crucial to distinguish between heparin-induced thrombocytopenia and thrombocytopenia caused by other drugs. A high level of suspicion should be employed in these cases.https://www.icrjournal.com/articleindex/icr.2022.23 |
| spellingShingle | Gian-Manuel Jiménez-Rodríguez Patricia Carmona-Levario José-Alberto Ayón-Martínez Aleksandra Gasecka Luis Eduardo Juárez-Orozco Antonio Reyes-Ortega Patricia Espinosa-González Gyna Alejandra Altamirano-Solorzano Guering Eid-Lidt Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach Interventional Cardiology: Reviews, Research, Resources |
| title | Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach |
| title_full | Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach |
| title_fullStr | Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach |
| title_full_unstemmed | Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach |
| title_short | Severe Acute Thrombocytopenia After Treatment with Tirofiban: A Case Series Approach |
| title_sort | severe acute thrombocytopenia after treatment with tirofiban a case series approach |
| url | https://www.icrjournal.com/articleindex/icr.2022.23 |
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