Engineering Organ-on-a-Chip to Accelerate Translational Research
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments. The organ-on-chip platform consists of microfluidic channels, cell culture...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/8/1200 |
| _version_ | 1797443401217474560 |
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| author | Jihoon Ko Dohyun Park Somin Lee Burcu Gumuscu Noo Li Jeon |
| author_facet | Jihoon Ko Dohyun Park Somin Lee Burcu Gumuscu Noo Li Jeon |
| author_sort | Jihoon Ko |
| collection | DOAJ |
| description | We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments. The organ-on-chip platform consists of microfluidic channels, cell culture chambers, and stimulus sources that emulate the in-vivo microenvironment. These platforms are typically engraved into an oxygen-permeable transparent material. Fabrication of these materials requires the use of microfabrication strategies, including soft lithography, 3D printing, and injection molding. Here we provide an overview of what is an organ-on-chip platform, where it can be used, what it is composed of, how it can be fabricated, and how it can be operated. In connection with this topic, we also introduce an overview of the recent applications, where different organs are modeled on the microscale using this technology. |
| first_indexed | 2024-03-09T12:55:31Z |
| format | Article |
| id | doaj.art-01fce78e58594427920b45f6f95704e5 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T12:55:31Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-01fce78e58594427920b45f6f95704e52023-11-30T22:00:00ZengMDPI AGMicromachines2072-666X2022-07-01138120010.3390/mi13081200Engineering Organ-on-a-Chip to Accelerate Translational ResearchJihoon Ko0Dohyun Park1Somin Lee2Burcu Gumuscu3Noo Li Jeon4Department of Mechanical Engineering, Seoul National University, Seoul 08826, KoreaBio-MAX Institute, Seoul National University, Seoul 08826, KoreaInterdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, KoreaBiosensors and Devices Laboratory, Biomedical Engineering Department, Institute for Complex Molecular Systems, Eindhoven Artificial Intelligence Systems Institute, Eindhoven University of Technology, 5600 MB Eindhoven, The NetherlandsDepartment of Mechanical Engineering, Seoul National University, Seoul 08826, KoreaWe guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments. The organ-on-chip platform consists of microfluidic channels, cell culture chambers, and stimulus sources that emulate the in-vivo microenvironment. These platforms are typically engraved into an oxygen-permeable transparent material. Fabrication of these materials requires the use of microfabrication strategies, including soft lithography, 3D printing, and injection molding. Here we provide an overview of what is an organ-on-chip platform, where it can be used, what it is composed of, how it can be fabricated, and how it can be operated. In connection with this topic, we also introduce an overview of the recent applications, where different organs are modeled on the microscale using this technology.https://www.mdpi.com/2072-666X/13/8/1200organ-on-a-chipmicrofabricationmicrophysiological systembiophysical stimulibiochemical stimuliin vitro cell culture |
| spellingShingle | Jihoon Ko Dohyun Park Somin Lee Burcu Gumuscu Noo Li Jeon Engineering Organ-on-a-Chip to Accelerate Translational Research Micromachines organ-on-a-chip microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture |
| title | Engineering Organ-on-a-Chip to Accelerate Translational Research |
| title_full | Engineering Organ-on-a-Chip to Accelerate Translational Research |
| title_fullStr | Engineering Organ-on-a-Chip to Accelerate Translational Research |
| title_full_unstemmed | Engineering Organ-on-a-Chip to Accelerate Translational Research |
| title_short | Engineering Organ-on-a-Chip to Accelerate Translational Research |
| title_sort | engineering organ on a chip to accelerate translational research |
| topic | organ-on-a-chip microfabrication microphysiological system biophysical stimuli biochemical stimuli in vitro cell culture |
| url | https://www.mdpi.com/2072-666X/13/8/1200 |
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