Lack of GNAQ and GNA11 germ-line mutations in familial melanoma pedigrees with uveal melanoma or blue nevi

Lack of GNAQ and GNA11 germ-line mutations in familial melanoma pedigrees with uveal melanoma or blue nevi

Approximately 10% of melanoma cases are familial, but only 25-40% of familial melanoma cases can be attributed to germ-line mutations in the CDKN2A - the most significant high-risk melanoma susceptibility locus identified to date. The pathogenic mutation(s) in most of the remaining familial melanoma...

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Bibliographic Details
Main Authors: Jason Ezra Hawkes, Jennifer eCampbell, Daniel eGarvin, Lisa eCannon Albright, Pamela eCassidy, Sancy A Leachman
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Oncology
Subjects:
Uveal Melanoma
familial melanoma
GNAQ
GNA11
germ-line
blue nevi
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00160/full

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