Role of sulfatide in normal and pathological cells and tissues
Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically degraded by a sulfatase (arylsulfatase A). Sulfatide is a multifunctional molecule for various biological fields includ...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-08-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520418486 |
| _version_ | 1818920460352487424 |
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| author | Tadanobu Takahashi Takashi Suzuki |
| author_facet | Tadanobu Takahashi Takashi Suzuki |
| author_sort | Tadanobu Takahashi |
| collection | DOAJ |
| description | Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically degraded by a sulfatase (arylsulfatase A). Sulfatide is a multifunctional molecule for various biological fields including the nervous system, insulin secretion, immune system, hemostasis/thrombosis, bacterial infection, and virus infection. Therefore, abnormal metabolism or expression change of sulfatide could cause various diseases. Here, we discuss the important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and influenza A virus. Our review will be helpful to achieve a comprehensive understanding of sulfatide, which serves as a fundamental target of prevention of and therapy for nervous disorders, diabetes mellitus, immunological diseases, cancer, and infectious diseases |
| first_indexed | 2024-12-20T01:22:06Z |
| format | Article |
| id | doaj.art-0201c0375ad4474293bf40058dd564d6 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-20T01:22:06Z |
| publishDate | 2012-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-0201c0375ad4474293bf40058dd564d62022-12-21T19:58:23ZengElsevierJournal of Lipid Research0022-22752012-08-0153814371450Role of sulfatide in normal and pathological cells and tissuesTadanobu Takahashi0Takashi Suzuki1Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program for Innovation in Human Health Sciences, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, JapanTo whom correspondence should be addressed. e-mail: Suzukit@u-shizuoka-ken.ac.jp.; To whom correspondence should be addressed. e-mail: Suzukit@u-shizuoka-ken.ac.jp.; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program for Innovation in Human Health Sciences, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, JapanSulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically degraded by a sulfatase (arylsulfatase A). Sulfatide is a multifunctional molecule for various biological fields including the nervous system, insulin secretion, immune system, hemostasis/thrombosis, bacterial infection, and virus infection. Therefore, abnormal metabolism or expression change of sulfatide could cause various diseases. Here, we discuss the important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and influenza A virus. Our review will be helpful to achieve a comprehensive understanding of sulfatide, which serves as a fundamental target of prevention of and therapy for nervous disorders, diabetes mellitus, immunological diseases, cancer, and infectious diseaseshttp://www.sciencedirect.com/science/article/pii/S0022227520418486bacterial infectionbiological functiondiabetesglycolipidhemostasisimmune system |
| spellingShingle | Tadanobu Takahashi Takashi Suzuki Role of sulfatide in normal and pathological cells and tissues Journal of Lipid Research bacterial infection biological function diabetes glycolipid hemostasis immune system |
| title | Role of sulfatide in normal and pathological cells and tissues |
| title_full | Role of sulfatide in normal and pathological cells and tissues |
| title_fullStr | Role of sulfatide in normal and pathological cells and tissues |
| title_full_unstemmed | Role of sulfatide in normal and pathological cells and tissues |
| title_short | Role of sulfatide in normal and pathological cells and tissues |
| title_sort | role of sulfatide in normal and pathological cells and tissues |
| topic | bacterial infection biological function diabetes glycolipid hemostasis immune system |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520418486 |
| work_keys_str_mv | AT tadanobutakahashi roleofsulfatideinnormalandpathologicalcellsandtissues AT takashisuzuki roleofsulfatideinnormalandpathologicalcellsandtissues |