Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses
A systematic literature review was conducted to identify and qualitatively assess randomized controlled trials in immunocompetent patients ≥ 18 years with head- region lesions of actinic keratoses who were treated with field-directed, lesion-directed and other therapies. Network meta-analysis was us...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2021-01-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3690
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| _version_ | 1798031445417000960 |
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| author | Khaled Ezzedine Caroline Painchault Melanie Brignone |
| author_facet | Khaled Ezzedine Caroline Painchault Melanie Brignone |
| author_sort | Khaled Ezzedine |
| collection | DOAJ |
| description | A systematic literature review was conducted to identify and qualitatively assess randomized controlled trials in immunocompetent patients ≥ 18 years with head- region lesions of actinic keratoses who were treated with field-directed, lesion-directed and other therapies. Network meta-analysis was used to quantitatively evaluate field-directed therapies (5-fluorouracil formulations, diclofenac sodium, imiquimod, ingenol mebutate, 5-aminolevulinic acid or methyl aminolevulinate plus photodynamic therapy) using complete clearance or partial clearance of actinic keratoses lesions, and adverse event-related withdrawals as a proxy of acceptability. Of 2,863 references identified, 75 trials reported in 151 publications were included. In summary, comparative network meta-analysis evaluation showed that 5-fluorouracil formulations were the most efficacious interventions examined. 5-fluorouracil 4%, which was recently approved, showed a comparable efficacy profile to 5-fluorouracil 5%, and had satisfactory acceptability outcomes. |
| first_indexed | 2024-04-11T19:57:37Z |
| format | Article |
| id | doaj.art-0201ed33e2254acc84dd5ee36ea31457 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-11T19:57:37Z |
| publishDate | 2021-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-0201ed33e2254acc84dd5ee36ea314572022-12-22T04:05:51ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572021-01-011011adv0035810.2340/00015555-36905936Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic KeratosesKhaled Ezzedine0Caroline PainchaultMelanie Brignone Department of Dermatology, Hôpital Henri Mondor, FR-94000 Creteil, France. A systematic literature review was conducted to identify and qualitatively assess randomized controlled trials in immunocompetent patients ≥ 18 years with head- region lesions of actinic keratoses who were treated with field-directed, lesion-directed and other therapies. Network meta-analysis was used to quantitatively evaluate field-directed therapies (5-fluorouracil formulations, diclofenac sodium, imiquimod, ingenol mebutate, 5-aminolevulinic acid or methyl aminolevulinate plus photodynamic therapy) using complete clearance or partial clearance of actinic keratoses lesions, and adverse event-related withdrawals as a proxy of acceptability. Of 2,863 references identified, 75 trials reported in 151 publications were included. In summary, comparative network meta-analysis evaluation showed that 5-fluorouracil formulations were the most efficacious interventions examined. 5-fluorouracil 4%, which was recently approved, showed a comparable efficacy profile to 5-fluorouracil 5%, and had satisfactory acceptability outcomes. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3690 actinic keratosis systematic literature review network meta-analysis field-directed intervention |
| spellingShingle | Khaled Ezzedine Caroline Painchault Melanie Brignone Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses Acta Dermato-Venereologica actinic keratosis systematic literature review network meta-analysis field-directed intervention |
| title | Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses |
| title_full | Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses |
| title_fullStr | Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses |
| title_full_unstemmed | Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses |
| title_short | Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses |
| title_sort | systematic literature review and network meta analysis of the efficacy and acceptability of interventions in actinic keratoses |
| topic | actinic keratosis systematic literature review network meta-analysis field-directed intervention |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3690
|
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