Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

Technologies that induce targeted protein degradation by small molecules have been developed recently. Chimeric small molecules such as Proteolysis Targeting Chimeras (PROTACs) and Specific and Non-genetic IAP-dependent Protein Erasers (SNIPERs), and E3 modulators such as thalidomides, hijack the ce...

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Bibliographic Details
Main Authors: Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Yoshinori Tsukumo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Chemistry
Subjects:
PROTAC
SNIPER
E3 modulator
ubiquitin
proteasome
protein degradation
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00849/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00849/full

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