Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons
The investigation of brain networks and neural circuits involves the crucial aspects of observing and modulating neurophysiological activity. Recently, opto-electrodes have emerged as an efficient tool for electrophysiological recording and optogenetic stimulation, which has greatly facilitated the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1195095/full |
| _version_ | 1797805732839555072 |
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| author | Qingping Zhang Qingping Zhang Qingping Zhang Wei Jing Wei Jing Wei Jing Shiping Wu Shiping Wu Shiping Wu Mengzheng Zhu Mengzheng Zhu Mengzheng Zhu Jingrui Jiang Jingrui Jiang Jingrui Jiang Xiang Liu Xiang Liu Xiang Liu Dian Yu Dian Yu Dian Yu Long Cheng Long Cheng Long Cheng Bin Feng Bin Feng Jianbin Wen Jianbin Wen Jianbin Wen Feng Xiong Youming Lu Youming Lu Youming Lu Huiyun Du Huiyun Du Huiyun Du |
| author_facet | Qingping Zhang Qingping Zhang Qingping Zhang Wei Jing Wei Jing Wei Jing Shiping Wu Shiping Wu Shiping Wu Mengzheng Zhu Mengzheng Zhu Mengzheng Zhu Jingrui Jiang Jingrui Jiang Jingrui Jiang Xiang Liu Xiang Liu Xiang Liu Dian Yu Dian Yu Dian Yu Long Cheng Long Cheng Long Cheng Bin Feng Bin Feng Jianbin Wen Jianbin Wen Jianbin Wen Feng Xiong Youming Lu Youming Lu Youming Lu Huiyun Du Huiyun Du Huiyun Du |
| author_sort | Qingping Zhang |
| collection | DOAJ |
| description | The investigation of brain networks and neural circuits involves the crucial aspects of observing and modulating neurophysiological activity. Recently, opto-electrodes have emerged as an efficient tool for electrophysiological recording and optogenetic stimulation, which has greatly facilitated the analysis of neural coding. However, implantation and electrode weight control have posed significant challenges in achieving long-term and multi-regional brain recording and stimulation. To address this issue, we have developed a mold and custom-printed circuit board-based opto-electrode. We report successful opto-electrode placement and high-quality electrophysiological recordings from the default mode network (DMN) of the mouse brain. This novel opto-electrode facilitates synchronous recording and stimulation in multiple brain regions and holds promise for advancing future research on neural circuits and networks. |
| first_indexed | 2024-03-13T05:56:30Z |
| format | Article |
| id | doaj.art-0203f553ba5547d5ad37afdb3b8c9330 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T05:56:30Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0203f553ba5547d5ad37afdb3b8c93302023-06-13T04:17:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-06-011710.3389/fnins.2023.11950951195095Development of a synchronous recording and photo-stimulating electrode in multiple brain neuronsQingping Zhang0Qingping Zhang1Qingping Zhang2Wei Jing3Wei Jing4Wei Jing5Shiping Wu6Shiping Wu7Shiping Wu8Mengzheng Zhu9Mengzheng Zhu10Mengzheng Zhu11Jingrui Jiang12Jingrui Jiang13Jingrui Jiang14Xiang Liu15Xiang Liu16Xiang Liu17Dian Yu18Dian Yu19Dian Yu20Long Cheng21Long Cheng22Long Cheng23Bin Feng24Bin Feng25Jianbin Wen26Jianbin Wen27Jianbin Wen28Feng Xiong29Youming Lu30Youming Lu31Youming Lu32Huiyun Du33Huiyun Du34Huiyun Du35Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, National Center for Magnetic Resonance in Wuhan, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathophysiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaWuhan Center for Brain Science, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Wuhan, ChinaThe investigation of brain networks and neural circuits involves the crucial aspects of observing and modulating neurophysiological activity. Recently, opto-electrodes have emerged as an efficient tool for electrophysiological recording and optogenetic stimulation, which has greatly facilitated the analysis of neural coding. However, implantation and electrode weight control have posed significant challenges in achieving long-term and multi-regional brain recording and stimulation. To address this issue, we have developed a mold and custom-printed circuit board-based opto-electrode. We report successful opto-electrode placement and high-quality electrophysiological recordings from the default mode network (DMN) of the mouse brain. This novel opto-electrode facilitates synchronous recording and stimulation in multiple brain regions and holds promise for advancing future research on neural circuits and networks.https://www.frontiersin.org/articles/10.3389/fnins.2023.1195095/fullelectrophysiological recordingoptogeneticmultichannel recordingdefault mode networkbrain networkneural circuit |
| spellingShingle | Qingping Zhang Qingping Zhang Qingping Zhang Wei Jing Wei Jing Wei Jing Shiping Wu Shiping Wu Shiping Wu Mengzheng Zhu Mengzheng Zhu Mengzheng Zhu Jingrui Jiang Jingrui Jiang Jingrui Jiang Xiang Liu Xiang Liu Xiang Liu Dian Yu Dian Yu Dian Yu Long Cheng Long Cheng Long Cheng Bin Feng Bin Feng Jianbin Wen Jianbin Wen Jianbin Wen Feng Xiong Youming Lu Youming Lu Youming Lu Huiyun Du Huiyun Du Huiyun Du Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons Frontiers in Neuroscience electrophysiological recording optogenetic multichannel recording default mode network brain network neural circuit |
| title | Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons |
| title_full | Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons |
| title_fullStr | Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons |
| title_full_unstemmed | Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons |
| title_short | Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons |
| title_sort | development of a synchronous recording and photo stimulating electrode in multiple brain neurons |
| topic | electrophysiological recording optogenetic multichannel recording default mode network brain network neural circuit |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1195095/full |
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