Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.
Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278327/pdf/?tool=EBI |
| _version_ | 1818338081466482688 |
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| author | Katherine J Kopeikina Susanne Wegmann Rose Pitstick George A Carlson Brian J Bacskai Rebecca A Betensky Bradley T Hyman Tara L Spires-Jones |
| author_facet | Katherine J Kopeikina Susanne Wegmann Rose Pitstick George A Carlson Brian J Bacskai Rebecca A Betensky Bradley T Hyman Tara L Spires-Jones |
| author_sort | Katherine J Kopeikina |
| collection | DOAJ |
| description | Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium homeostasis, synapse loss and pathological changes in tau. Here we test the hypothesis that pathological changes in tau are associated with changes in calcium by utilizing in vivo calcium imaging in adult rTg4510 mice that exhibit severe tau pathology due to over-expression of human mutant P301L tau. We observe prominent dendritic spine loss without disruptions in calcium homeostasis, indicating that tangles do not disrupt this fundamental feature of neuronal health, and that tau likely induces spine loss in a calcium-independent manner. |
| first_indexed | 2024-12-13T15:05:26Z |
| format | Article |
| id | doaj.art-020431432a1f4c968396a817fd88776f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:05:26Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-020431432a1f4c968396a817fd88776f2022-12-21T23:41:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8083410.1371/journal.pone.0080834Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.Katherine J KopeikinaSusanne WegmannRose PitstickGeorge A CarlsonBrian J BacskaiRebecca A BetenskyBradley T HymanTara L Spires-JonesNeurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few studies have probed the link between calcium homeostasis, synapse loss and pathological changes in tau. Here we test the hypothesis that pathological changes in tau are associated with changes in calcium by utilizing in vivo calcium imaging in adult rTg4510 mice that exhibit severe tau pathology due to over-expression of human mutant P301L tau. We observe prominent dendritic spine loss without disruptions in calcium homeostasis, indicating that tangles do not disrupt this fundamental feature of neuronal health, and that tau likely induces spine loss in a calcium-independent manner.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278327/pdf/?tool=EBI |
| spellingShingle | Katherine J Kopeikina Susanne Wegmann Rose Pitstick George A Carlson Brian J Bacskai Rebecca A Betensky Bradley T Hyman Tara L Spires-Jones Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS ONE |
| title | Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. |
| title_full | Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. |
| title_fullStr | Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. |
| title_full_unstemmed | Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. |
| title_short | Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. |
| title_sort | tau causes synapse loss without disrupting calcium homeostasis in the rtg4510 model of tauopathy |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278327/pdf/?tool=EBI |
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