The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances
The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd<sup>3+&l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5072 |
| _version_ | 1827703020272484352 |
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| author | Xiaodong Li Yanhong Sun Lina Ma Guifeng Liu Zhenxin Wang |
| author_facet | Xiaodong Li Yanhong Sun Lina Ma Guifeng Liu Zhenxin Wang |
| author_sort | Xiaodong Li |
| collection | DOAJ |
| description | The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd<sup>3+</sup>) complex-based MRCAs have achieved great success in clinical practice, the Gd<sup>3+</sup>-complexes have several inherent drawbacks including Gd<sup>3+</sup> leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation. |
| first_indexed | 2024-03-10T15:09:36Z |
| format | Article |
| id | doaj.art-0204686e17b746e8868172123b7fd94a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:09:36Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0204686e17b746e8868172123b7fd94a2023-11-20T19:27:09ZengMDPI AGMolecules1420-30492020-11-012521507210.3390/molecules25215072The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent AdvancesXiaodong Li0Yanhong Sun1Lina Ma2Guifeng Liu3Zhenxin Wang4Department of Radiology, China-Japan Union Hospital of Jilin University, Xiantai Street, Changchun 130033, ChinaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, ChinaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, ChinaDepartment of Radiology, China-Japan Union Hospital of Jilin University, Xiantai Street, Changchun 130033, ChinaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, ChinaThe advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd<sup>3+</sup>) complex-based MRCAs have achieved great success in clinical practice, the Gd<sup>3+</sup>-complexes have several inherent drawbacks including Gd<sup>3+</sup> leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation.https://www.mdpi.com/1420-3049/25/21/5072magnetic resonance imaging contrast agentsrenal clearancenanodotsgadolinium (III)-based composites |
| spellingShingle | Xiaodong Li Yanhong Sun Lina Ma Guifeng Liu Zhenxin Wang The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances Molecules magnetic resonance imaging contrast agents renal clearance nanodots gadolinium (III)-based composites |
| title | The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances |
| title_full | The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances |
| title_fullStr | The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances |
| title_full_unstemmed | The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances |
| title_short | The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances |
| title_sort | renal clearable magnetic resonance imaging contrast agents state of the art and recent advances |
| topic | magnetic resonance imaging contrast agents renal clearance nanodots gadolinium (III)-based composites |
| url | https://www.mdpi.com/1420-3049/25/21/5072 |
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