Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/15/3/1154/ |
| _version_ | 1818834459851489280 |
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| author | Dong-Sheng Ma Hua Zhang Wei Wang Lijuan Liu Chaoyu Wang |
| author_facet | Dong-Sheng Ma Hua Zhang Wei Wang Lijuan Liu Chaoyu Wang |
| author_sort | Dong-Sheng Ma |
| collection | DOAJ |
| description | (S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields. |
| first_indexed | 2024-12-19T02:35:10Z |
| format | Article |
| id | doaj.art-02047b6707a1421fa953ed2c21a868f2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T02:35:10Z |
| publishDate | 2010-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-02047b6707a1421fa953ed2c21a868f22022-12-21T20:39:27ZengMDPI AGMolecules1420-30492010-03-011531154116010.3390/molecules15031154Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the LigandDong-Sheng MaHua ZhangWei WangLijuan LiuChaoyu Wang(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.http://www.mdpi.com/1420-3049/15/3/1154/copper(S)-N-methylpyrrolidine-2-carboxylatearylationsamides |
| spellingShingle | Dong-Sheng Ma Hua Zhang Wei Wang Lijuan Liu Chaoyu Wang Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand Molecules copper (S)-N-methylpyrrolidine-2-carboxylate arylations amides |
| title | Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand |
| title_full | Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand |
| title_fullStr | Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand |
| title_full_unstemmed | Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand |
| title_short | Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand |
| title_sort | copper catalyzed n arylation of amides using s n methylpyrrolidine 2 carboxylate as the ligand |
| topic | copper (S)-N-methylpyrrolidine-2-carboxylate arylations amides |
| url | http://www.mdpi.com/1420-3049/15/3/1154/ |
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