Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation
Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still uncommon in clinical use despite decades of research and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/8/1193 |
| _version_ | 1827684337877778432 |
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| author | David J. Lundy Helen Nguyễn Patrick C. H. Hsieh |
| author_facet | David J. Lundy Helen Nguyễn Patrick C. H. Hsieh |
| author_sort | David J. Lundy |
| collection | DOAJ |
| description | Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still uncommon in clinical use despite decades of research and development. Here, we provide an update on nano-carrier strategies for improving brain drug delivery for treatment of brain tumors, focusing on liposomes, extracellular vesicles and biomimetic strategies as the most clinically feasible strategies. Finally, we describe the obstacles in translation of these technologies including pre-clinical models, analytical methods and regulatory issues. |
| first_indexed | 2024-03-10T08:27:55Z |
| format | Article |
| id | doaj.art-020b31e7e31e42efbc6501175b21dbd9 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:27:55Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-020b31e7e31e42efbc6501175b21dbd92023-11-22T09:14:08ZengMDPI AGPharmaceutics1999-49232021-08-01138119310.3390/pharmaceutics13081193Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical TranslationDavid J. Lundy0Helen Nguyễn1Patrick C. H. Hsieh2Graduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Biomedical Materials & Tissue Engineering, Taipei Medical University, Taipei 110, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, TaiwanTreatment of brain tumors is challenging since the blood–brain tumor barrier prevents chemotherapy drugs from reaching the tumor site in sufficient concentrations. Nanomedicines have great potential for therapy of brain disorders but are still uncommon in clinical use despite decades of research and development. Here, we provide an update on nano-carrier strategies for improving brain drug delivery for treatment of brain tumors, focusing on liposomes, extracellular vesicles and biomimetic strategies as the most clinically feasible strategies. Finally, we describe the obstacles in translation of these technologies including pre-clinical models, analytical methods and regulatory issues.https://www.mdpi.com/1999-4923/13/8/1193blood–brain barriernanomedicineliposomebrain tumorexosomeglioblastoma multiforme |
| spellingShingle | David J. Lundy Helen Nguyễn Patrick C. H. Hsieh Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation Pharmaceutics blood–brain barrier nanomedicine liposome brain tumor exosome glioblastoma multiforme |
| title | Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation |
| title_full | Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation |
| title_fullStr | Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation |
| title_full_unstemmed | Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation |
| title_short | Emerging Nano-Carrier Strategies for Brain Tumor Drug Delivery and Considerations for Clinical Translation |
| title_sort | emerging nano carrier strategies for brain tumor drug delivery and considerations for clinical translation |
| topic | blood–brain barrier nanomedicine liposome brain tumor exosome glioblastoma multiforme |
| url | https://www.mdpi.com/1999-4923/13/8/1193 |
| work_keys_str_mv | AT davidjlundy emergingnanocarrierstrategiesforbraintumordrugdeliveryandconsiderationsforclinicaltranslation AT helennguyen emergingnanocarrierstrategiesforbraintumordrugdeliveryandconsiderationsforclinicaltranslation AT patrickchhsieh emergingnanocarrierstrategiesforbraintumordrugdeliveryandconsiderationsforclinicaltranslation |