Damage control of epithelial barrier function in dynamic environments
Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital role is known as epithelial barrier function. Epithelial cells are arranged l...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2024-06-01
|
Series: | European Journal of Cell Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S017193352400027X |
_version_ | 1827207889704452096 |
---|---|
author | Tomohito Higashi Akira C. Saito Hideki Chiba |
author_facet | Tomohito Higashi Akira C. Saito Hideki Chiba |
author_sort | Tomohito Higashi |
collection | DOAJ |
description | Epithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital role is known as epithelial barrier function. Epithelial cells are arranged like cobblestones and intricately bind together to form an epithelial sheet that upholds this barrier function. Central to the restriction of solute and fluid diffusion through intercellular spaces are occluding junctions, tight junctions in vertebrates and septate junctions in invertebrates. As part of epithelial tissues, cells undergo constant renewal, with older cells being replaced by new ones. Simultaneously, the epithelial tissue undergoes relative rearrangement, elongating, and shifting directionally as a whole. The movement or shape changes within the epithelial sheet necessitate significant deformation and reconnection of occluding junctions. Recent advancements have shed light on the intricate mechanisms through which epithelial cells sustain their barrier function in dynamic environments. This review aims to introduce these noteworthy findings and discuss some of the questions that remain unanswered. |
first_indexed | 2024-04-24T13:11:17Z |
format | Article |
id | doaj.art-020b5476d5364f00a527107bb536d30f |
institution | Directory Open Access Journal |
issn | 0171-9335 |
language | English |
last_indexed | 2025-03-21T12:47:15Z |
publishDate | 2024-06-01 |
publisher | Elsevier |
record_format | Article |
series | European Journal of Cell Biology |
spelling | doaj.art-020b5476d5364f00a527107bb536d30f2024-06-27T04:39:18ZengElsevierEuropean Journal of Cell Biology0171-93352024-06-011032151410Damage control of epithelial barrier function in dynamic environmentsTomohito Higashi0Akira C. Saito1Hideki Chiba2Correspondence to: Department of Basic Pathology, Fukushima Medical University, 1 Hikariga-oka, Fukushima 960-1295, Japan.; Department of Basic Pathology, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Basic Pathology, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Basic Pathology, Fukushima Medical University, Fukushima 960-1295, JapanEpithelial tissues cover the surfaces and lumens of the internal organs of multicellular animals and crucially contribute to internal environment homeostasis by delineating distinct compartments within the body. This vital role is known as epithelial barrier function. Epithelial cells are arranged like cobblestones and intricately bind together to form an epithelial sheet that upholds this barrier function. Central to the restriction of solute and fluid diffusion through intercellular spaces are occluding junctions, tight junctions in vertebrates and septate junctions in invertebrates. As part of epithelial tissues, cells undergo constant renewal, with older cells being replaced by new ones. Simultaneously, the epithelial tissue undergoes relative rearrangement, elongating, and shifting directionally as a whole. The movement or shape changes within the epithelial sheet necessitate significant deformation and reconnection of occluding junctions. Recent advancements have shed light on the intricate mechanisms through which epithelial cells sustain their barrier function in dynamic environments. This review aims to introduce these noteworthy findings and discuss some of the questions that remain unanswered.http://www.sciencedirect.com/science/article/pii/S017193352400027Xtight junctionsseptate junctionsbarrier functionepithelial cells |
spellingShingle | Tomohito Higashi Akira C. Saito Hideki Chiba Damage control of epithelial barrier function in dynamic environments European Journal of Cell Biology tight junctions septate junctions barrier function epithelial cells |
title | Damage control of epithelial barrier function in dynamic environments |
title_full | Damage control of epithelial barrier function in dynamic environments |
title_fullStr | Damage control of epithelial barrier function in dynamic environments |
title_full_unstemmed | Damage control of epithelial barrier function in dynamic environments |
title_short | Damage control of epithelial barrier function in dynamic environments |
title_sort | damage control of epithelial barrier function in dynamic environments |
topic | tight junctions septate junctions barrier function epithelial cells |
url | http://www.sciencedirect.com/science/article/pii/S017193352400027X |
work_keys_str_mv | AT tomohitohigashi damagecontrolofepithelialbarrierfunctionindynamicenvironments AT akiracsaito damagecontrolofepithelialbarrierfunctionindynamicenvironments AT hidekichiba damagecontrolofepithelialbarrierfunctionindynamicenvironments |