New Development of Disaster-Related and Tropical Infectious Diseases Control
As described in Japanese essay (Hojoki), written around 1200, various disasters such as big fires, earthquakes, and famines have occurred in Japan. Asian countries have been suffering from the disasters; furthermore, natural disasters are increasing due to global warming. Because tropical-infectious...
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MDPI AG
2020-03-01
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| Online Access: | https://www.mdpi.com/2571-841X/3/1/5 |
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| author | Gaowa Bai Toshiro Niki Haruhisa Kikuchi Ayako Sumi Nobuyuki Kobayashi Takahiro Haruyama Jing Zhang Haorile Chagan-Yasutan Toshio Hattori |
| author_facet | Gaowa Bai Toshiro Niki Haruhisa Kikuchi Ayako Sumi Nobuyuki Kobayashi Takahiro Haruyama Jing Zhang Haorile Chagan-Yasutan Toshio Hattori |
| author_sort | Gaowa Bai |
| collection | DOAJ |
| description | As described in Japanese essay (Hojoki), written around 1200, various disasters such as big fires, earthquakes, and famines have occurred in Japan. Asian countries have been suffering from the disasters; furthermore, natural disasters are increasing due to global warming. Because tropical-infectious diseases are often disaster-related infectious diseases (DRIDs), the strategies against the former kind of disease could be applicable to DRIDs. Meteorological analysis of the occurrence of DRIDs using a method of time series analysis is important. In situations of disasters, it is desirable if you can identify the pathogen and identify disease severity simultaneously. A dipstick DNA chromatography assay termed as Single-Tag Hybridization—Printed Array Strip (STH—PAS) system was developed based on the DNA sequences of various mosquito-borne diseases. The plasma levels of matricellular proteins including galectin-9 (Gal-9) and osteopontin (OPN) were found to reflect the disease severities in the dengue virus and other DIRDs. Because both proteins have been reported to be immune-check molecules, their inhibition might enhance the immune system against pathogens. We found that brefelamide derivatives could inhibit OPN and other inflammatory molecules synthesis. Very recently, different derivatives were found to inhibit PD-L1 transcription. Applications of these agents should be considered as multi-step strategies against DRIDs. |
| first_indexed | 2024-04-11T19:57:37Z |
| format | Article |
| id | doaj.art-020cdbd60bd94ed18d452bbaa2fa1297 |
| institution | Directory Open Access Journal |
| issn | 2571-841X |
| language | English |
| last_indexed | 2024-04-11T19:57:37Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj.art-020cdbd60bd94ed18d452bbaa2fa12972022-12-22T04:05:54ZengMDPI AGReports2571-841X2020-03-0131510.3390/reports3010005reports3010005New Development of Disaster-Related and Tropical Infectious Diseases ControlGaowa Bai0Toshiro Niki1Haruhisa Kikuchi2Ayako Sumi3Nobuyuki Kobayashi4Takahiro Haruyama5Jing Zhang6Haorile Chagan-Yasutan7Toshio Hattori8Department of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, JapanDepartment of Immunology, Faculty of Medicine, Kagawa University, Kita-gun 761-0701, JapanLaboratory of Natural Product Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanDepartment of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8556, JapanResearch Center AVSS Co., Ltd., 5-8 Suzaki, Urumashi 904-2234, JapanResearch Center AVSS Co., Ltd., 5-8 Suzaki, Urumashi 904-2234, JapanResearch and Development Center, FUSO Pharmaceutical Institute, LTD, Osaka 536-0025, JapanDepartment of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, JapanDepartment of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, JapanAs described in Japanese essay (Hojoki), written around 1200, various disasters such as big fires, earthquakes, and famines have occurred in Japan. Asian countries have been suffering from the disasters; furthermore, natural disasters are increasing due to global warming. Because tropical-infectious diseases are often disaster-related infectious diseases (DRIDs), the strategies against the former kind of disease could be applicable to DRIDs. Meteorological analysis of the occurrence of DRIDs using a method of time series analysis is important. In situations of disasters, it is desirable if you can identify the pathogen and identify disease severity simultaneously. A dipstick DNA chromatography assay termed as Single-Tag Hybridization—Printed Array Strip (STH—PAS) system was developed based on the DNA sequences of various mosquito-borne diseases. The plasma levels of matricellular proteins including galectin-9 (Gal-9) and osteopontin (OPN) were found to reflect the disease severities in the dengue virus and other DIRDs. Because both proteins have been reported to be immune-check molecules, their inhibition might enhance the immune system against pathogens. We found that brefelamide derivatives could inhibit OPN and other inflammatory molecules synthesis. Very recently, different derivatives were found to inhibit PD-L1 transcription. Applications of these agents should be considered as multi-step strategies against DRIDs.https://www.mdpi.com/2571-841X/3/1/5disastertropicalinfectious diseasesglobal warmingssth-pasgalectin 9osteopontinbrefelamide |
| spellingShingle | Gaowa Bai Toshiro Niki Haruhisa Kikuchi Ayako Sumi Nobuyuki Kobayashi Takahiro Haruyama Jing Zhang Haorile Chagan-Yasutan Toshio Hattori New Development of Disaster-Related and Tropical Infectious Diseases Control Reports disaster tropical infectious diseases global warmings sth-pas galectin 9 osteopontin brefelamide |
| title | New Development of Disaster-Related and Tropical Infectious Diseases Control |
| title_full | New Development of Disaster-Related and Tropical Infectious Diseases Control |
| title_fullStr | New Development of Disaster-Related and Tropical Infectious Diseases Control |
| title_full_unstemmed | New Development of Disaster-Related and Tropical Infectious Diseases Control |
| title_short | New Development of Disaster-Related and Tropical Infectious Diseases Control |
| title_sort | new development of disaster related and tropical infectious diseases control |
| topic | disaster tropical infectious diseases global warmings sth-pas galectin 9 osteopontin brefelamide |
| url | https://www.mdpi.com/2571-841X/3/1/5 |
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