[11C]glyburide PET imaging for quantitative determination of the importance of Organic Anion-Transporting Polypeptide transporter function in the human liver and whole-body

[11C]glyburide PET imaging for quantitative determination of the importance of Organic Anion-Transporting Polypeptide transporter function in the human liver and whole-body

Organic Anion-Transporting Polypeptides (OATPs) are known to control the liver uptake of many drugs. Non-hepatic expression of OATPs has been reported although functional importance for whole-body pharmacokinetics (WBPK) remains unknown. Glyburide is a well described substrate of several hepatic and...

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Bibliographic Details
Main Authors: Solène Marie, Louise Breuil, Zacharias Chalampalakis, Laurent Becquemont, Céline Verstuyft, Anne-Lise Lecoq, Fabien Caillé, Philippe Gervais, Vincent Lebon, Claude Comtat, Michel Bottlaender, Nicolas Tournier
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
[11C]glyburide
Hepatocyte
Liver
PET
Pharmacokinetics
Positron emission tomography
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222201383X

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