Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism
Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular ba...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/1/17 |
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| author | Qishun Zhou Jakob Kerbl-Knapp Fangrong Zhang Melanie Korbelius Katharina Barbara Kuentzel Nemanja Vujić Alena Akhmetshina Gerd Hörl Margret Paar Ernst Steyrer Dagmar Kratky Tobias Madl |
| author_facet | Qishun Zhou Jakob Kerbl-Knapp Fangrong Zhang Melanie Korbelius Katharina Barbara Kuentzel Nemanja Vujić Alena Akhmetshina Gerd Hörl Margret Paar Ernst Steyrer Dagmar Kratky Tobias Madl |
| author_sort | Qishun Zhou |
| collection | DOAJ |
| description | Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular basis of the aging process. However, the metabolic changes in tissues responsible for food intake and lipid storage have remained unexplored. In this study, we aimed to investigate aging-related metabolic alterations in these tissues. To fill this gap, we employed NMR-based metabolomics in several tissues, including different parts of the intestine (duodenum, jejunum, ileum) and brown/white adipose tissues (BAT, WAT), of young (9–10 weeks) and old (96–104 weeks) wild-type (mixed genetic background of 129/J and C57BL/6) mice. We, further, included plasma and skeletal muscle of the same mice to verify previous results. Strikingly, we found that duodenum, jejunum, ileum, and WAT do not metabolically age. In contrast, plasma, skeletal muscle, and BAT show a strong metabolic aging phenotype. Overall, we provide first insights into the metabolic changes of tissues essential for nutrient uptake and lipid storage and have identified biomarkers for metabolites that could be further explored, to study the molecular mechanisms of aging. |
| first_indexed | 2024-03-10T00:57:18Z |
| format | Article |
| id | doaj.art-020d70e6ce124613953e12aec8f5e359 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T00:57:18Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-020d70e6ce124613953e12aec8f5e3592023-11-23T14:39:36ZengMDPI AGMetabolites2218-19892021-12-011211710.3390/metabo12010017Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy MetabolismQishun Zhou0Jakob Kerbl-Knapp1Fangrong Zhang2Melanie Korbelius3Katharina Barbara Kuentzel4Nemanja Vujić5Alena Akhmetshina6Gerd Hörl7Margret Paar8Ernst Steyrer9Dagmar Kratky10Tobias Madl11Gottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaOtto-Loewi Research Center, Physiological Chemistry, Medical University of Graz, 8010 Graz, AustriaOtto-Loewi Research Center, Physiological Chemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaGottfried Schatz Research Center for Cell Signaling, Metabolism and Ageing, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, AustriaEnergy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and have provided critical information to elucidate the molecular basis of the aging process. However, the metabolic changes in tissues responsible for food intake and lipid storage have remained unexplored. In this study, we aimed to investigate aging-related metabolic alterations in these tissues. To fill this gap, we employed NMR-based metabolomics in several tissues, including different parts of the intestine (duodenum, jejunum, ileum) and brown/white adipose tissues (BAT, WAT), of young (9–10 weeks) and old (96–104 weeks) wild-type (mixed genetic background of 129/J and C57BL/6) mice. We, further, included plasma and skeletal muscle of the same mice to verify previous results. Strikingly, we found that duodenum, jejunum, ileum, and WAT do not metabolically age. In contrast, plasma, skeletal muscle, and BAT show a strong metabolic aging phenotype. Overall, we provide first insights into the metabolic changes of tissues essential for nutrient uptake and lipid storage and have identified biomarkers for metabolites that could be further explored, to study the molecular mechanisms of aging.https://www.mdpi.com/2218-1989/12/1/17agingNMR spectroscopymiceenergy metabolismfatintestine |
| spellingShingle | Qishun Zhou Jakob Kerbl-Knapp Fangrong Zhang Melanie Korbelius Katharina Barbara Kuentzel Nemanja Vujić Alena Akhmetshina Gerd Hörl Margret Paar Ernst Steyrer Dagmar Kratky Tobias Madl Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism Metabolites aging NMR spectroscopy mice energy metabolism fat intestine |
| title | Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism |
| title_full | Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism |
| title_fullStr | Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism |
| title_full_unstemmed | Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism |
| title_short | Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism |
| title_sort | metabolomic profiles of mouse tissues reveal an interplay between aging and energy metabolism |
| topic | aging NMR spectroscopy mice energy metabolism fat intestine |
| url | https://www.mdpi.com/2218-1989/12/1/17 |
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