Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors
Vessel size imaging was used to assess changes in the average vessel size of Shionogi tumors throughout the tumor growth cycle. Changes in R2 and R2* relaxivities caused by the injection of a superparamagnetic contrast agent (ferumoxtran-10) were measured using a 2.35-T animal magnetic resonance ima...
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| Format: | Article |
| Language: | English |
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Elsevier
2007-07-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558607800819 |
| _version_ | 1818956498776096768 |
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| author | Trevor P. Wade Piotr Kozlowski |
| author_facet | Trevor P. Wade Piotr Kozlowski |
| author_sort | Trevor P. Wade |
| collection | DOAJ |
| description | Vessel size imaging was used to assess changes in the average vessel size of Shionogi tumors throughout the tumor growth cycle. Changes in R2 and R2* relaxivities caused by the injection of a superparamagnetic contrast agent (ferumoxtran-10) were measured using a 2.35-T animal magnetic resonance imaging system, and average vessel size index (VSI) was calculated for each stage of tumor progression: growth, regression, and relapse. Statistical analysis using Spearman rank correlation test showed no dependence between vessel size and tumor volume at any stage of the tumor growth cycle. Paired Student's t test was used to assess the statistical significance of the differences in average vessel size for the three stages of the tumor growth cycle. The average VSI for regressing tumors (15.1 ± 6.6 wm) was significantly lower than that for growing tumors (35.2 ± 25.5 μm; P < .01). Relapsing tumors also had an average VSI (45.4 ± 41.8 μm) higher than that of regressing tumors, although the difference was not statistically significant (P = .067). This study shows that VSI imaging is a viable method for the noninvasive monitoring of angiogenesis during the progression of a Shionogi tumor from androgen dependence to androgen independence. |
| first_indexed | 2024-12-20T10:54:55Z |
| format | Article |
| id | doaj.art-020db79126964c9fa098df06611eca74 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 1522-8002 |
| language | English |
| last_indexed | 2024-12-20T10:54:55Z |
| publishDate | 2007-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-020db79126964c9fa098df06611eca742022-12-21T19:43:09ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022007-07-019756356810.1593/neo.07313Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi TumorsTrevor P. Wade0Piotr Kozlowski1Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, CanadaThe Prostate Center at Vancouver General Hospital, Vancouver, BC, CanadaVessel size imaging was used to assess changes in the average vessel size of Shionogi tumors throughout the tumor growth cycle. Changes in R2 and R2* relaxivities caused by the injection of a superparamagnetic contrast agent (ferumoxtran-10) were measured using a 2.35-T animal magnetic resonance imaging system, and average vessel size index (VSI) was calculated for each stage of tumor progression: growth, regression, and relapse. Statistical analysis using Spearman rank correlation test showed no dependence between vessel size and tumor volume at any stage of the tumor growth cycle. Paired Student's t test was used to assess the statistical significance of the differences in average vessel size for the three stages of the tumor growth cycle. The average VSI for regressing tumors (15.1 ± 6.6 wm) was significantly lower than that for growing tumors (35.2 ± 25.5 μm; P < .01). Relapsing tumors also had an average VSI (45.4 ± 41.8 μm) higher than that of regressing tumors, although the difference was not statistically significant (P = .067). This study shows that VSI imaging is a viable method for the noninvasive monitoring of angiogenesis during the progression of a Shionogi tumor from androgen dependence to androgen independence.http://www.sciencedirect.com/science/article/pii/S1476558607800819Magnetic resonance imagingvessel size imagingangiogenesishormone-dependent tumorstumor microenvironment |
| spellingShingle | Trevor P. Wade Piotr Kozlowski Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors Neoplasia: An International Journal for Oncology Research Magnetic resonance imaging vessel size imaging angiogenesis hormone-dependent tumors tumor microenvironment |
| title | Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors |
| title_full | Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors |
| title_fullStr | Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors |
| title_full_unstemmed | Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors |
| title_short | Longitudinal Studies of Angiogenesis in Hormone-Dependent Shionogi Tumors |
| title_sort | longitudinal studies of angiogenesis in hormone dependent shionogi tumors |
| topic | Magnetic resonance imaging vessel size imaging angiogenesis hormone-dependent tumors tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S1476558607800819 |
| work_keys_str_mv | AT trevorpwade longitudinalstudiesofangiogenesisinhormonedependentshionogitumors AT piotrkozlowski longitudinalstudiesofangiogenesisinhormonedependentshionogitumors |