Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction
Background: Posttraumatic stress disorder (PTSD) is a frequently observed stress-related disorder after acute myocardial infarction (AMI) and it is characterized by numerous symptoms, such as flashbacks, intrusions and anxiety, as well as uncontrollable thoughts and feelings related to the trauma. B...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | European Journal of Psychotraumatology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20008198.2021.1920201 |
| _version_ | 1797844504127995904 |
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| author | Andreas Baranyi Dietmar Enko Dirk von Lewinski Hans-Bernd Rothenhäusler Omid Amouzadeh-Ghadikolai Hanns Harpf Leonhard Harpf Heimo Traninger Barbara Obermayer-Pietsch Melanie Schweinzer Celine K. Braun Andreas Meinitzer |
| author_facet | Andreas Baranyi Dietmar Enko Dirk von Lewinski Hans-Bernd Rothenhäusler Omid Amouzadeh-Ghadikolai Hanns Harpf Leonhard Harpf Heimo Traninger Barbara Obermayer-Pietsch Melanie Schweinzer Celine K. Braun Andreas Meinitzer |
| author_sort | Andreas Baranyi |
| collection | DOAJ |
| description | Background: Posttraumatic stress disorder (PTSD) is a frequently observed stress-related disorder after acute myocardial infarction (AMI) and it is characterized by numerous symptoms, such as flashbacks, intrusions and anxiety, as well as uncontrollable thoughts and feelings related to the trauma. Biological correlates of severe stress might contribute to identifying PTSD-vulnerable patients at an early stage. Objective: Aims of the study were (1) to determine whether blood levels of trimethylamine N-oxide (TMAO) vary immediately after AMI in patients with/without AMI-induced PTSD symptomatology, (2) to investigate whether TMAO is a potential biomarker that might be useful in the prediction of PTSD and the PTSD symptom subclusters re-experiencing, avoidance and hyperarousal, and (3) to investigate whether TMAO varies immediately after AMI in patients with/without depression 6 months after AMI. Method: A total of 114 AMI patients were assessed with the Hamilton-Depression Scale after admission to the hospital and 6 months later. The Clinician Administered PTSD Scale for DSM-5 was used to explore PTSD-symptoms at the time of AMI and 6 months after AMI. To assess patients’ TMAO status, serum samples were collected at hospitalization and 6 months after AMI. Results: Participants with PTSD-symptomatology had significantly higher TMAO levels immediately after AMI than patients without PTSD-symptoms (ANCOVA: TMAO(PTSD x time), F = 4.544, df = 1, p = 0.035). With the inclusion of additional clinical predictors in a hierarchical logistic regression model, TMAO became a significant predictor of PTSD-symptomatology. No significant differences in TMAO levels immediately after AMI were detected between individuals with/without depression 6 months after AMI. Conclusions: An elevated TMAO level immediately after AMI might reflect severe stress in PTSD-vulnerable patients, which might also lead to a short-term increase in gut permeability to trimethylamine, the precursor of TMAO. Thus, an elevated TMAO level might be a biological correlate for severe stress that is associated with vulnerability to PTSD. |
| first_indexed | 2024-04-09T17:24:26Z |
| format | Article |
| id | doaj.art-020e63e886b2419c9e4b51267b86040c |
| institution | Directory Open Access Journal |
| issn | 2000-8066 |
| language | English |
| last_indexed | 2024-04-09T17:24:26Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of Psychotraumatology |
| spelling | doaj.art-020e63e886b2419c9e4b51267b86040c2023-04-18T14:59:09ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662021-01-0112110.1080/20008198.2021.19202011920201Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarctionAndreas Baranyi0Dietmar Enko1Dirk von Lewinski2Hans-Bernd Rothenhäusler3Omid Amouzadeh-Ghadikolai4Hanns Harpf5Leonhard Harpf6Heimo Traninger7Barbara Obermayer-Pietsch8Melanie Schweinzer9Celine K. Braun10Andreas Meinitzer11Medical University of GrazMedical University of GrazMedical University of GrazMedical University of GrazState Hospital Graz IIZARG Zentrum Für Ambulante Rehabilitation GmbHZARG Zentrum Für Ambulante Rehabilitation GmbHZARG Zentrum Für Ambulante Rehabilitation GmbHMedical University of GrazMedical University of GrazMedical University of GrazMedical University of GrazBackground: Posttraumatic stress disorder (PTSD) is a frequently observed stress-related disorder after acute myocardial infarction (AMI) and it is characterized by numerous symptoms, such as flashbacks, intrusions and anxiety, as well as uncontrollable thoughts and feelings related to the trauma. Biological correlates of severe stress might contribute to identifying PTSD-vulnerable patients at an early stage. Objective: Aims of the study were (1) to determine whether blood levels of trimethylamine N-oxide (TMAO) vary immediately after AMI in patients with/without AMI-induced PTSD symptomatology, (2) to investigate whether TMAO is a potential biomarker that might be useful in the prediction of PTSD and the PTSD symptom subclusters re-experiencing, avoidance and hyperarousal, and (3) to investigate whether TMAO varies immediately after AMI in patients with/without depression 6 months after AMI. Method: A total of 114 AMI patients were assessed with the Hamilton-Depression Scale after admission to the hospital and 6 months later. The Clinician Administered PTSD Scale for DSM-5 was used to explore PTSD-symptoms at the time of AMI and 6 months after AMI. To assess patients’ TMAO status, serum samples were collected at hospitalization and 6 months after AMI. Results: Participants with PTSD-symptomatology had significantly higher TMAO levels immediately after AMI than patients without PTSD-symptoms (ANCOVA: TMAO(PTSD x time), F = 4.544, df = 1, p = 0.035). With the inclusion of additional clinical predictors in a hierarchical logistic regression model, TMAO became a significant predictor of PTSD-symptomatology. No significant differences in TMAO levels immediately after AMI were detected between individuals with/without depression 6 months after AMI. Conclusions: An elevated TMAO level immediately after AMI might reflect severe stress in PTSD-vulnerable patients, which might also lead to a short-term increase in gut permeability to trimethylamine, the precursor of TMAO. Thus, an elevated TMAO level might be a biological correlate for severe stress that is associated with vulnerability to PTSD.http://dx.doi.org/10.1080/20008198.2021.1920201trimethylamine n-oxide (tmao)acute myocardial infarctiongut permeabilityposttraumatic stress disorder (ptsd)depressionbiomarker |
| spellingShingle | Andreas Baranyi Dietmar Enko Dirk von Lewinski Hans-Bernd Rothenhäusler Omid Amouzadeh-Ghadikolai Hanns Harpf Leonhard Harpf Heimo Traninger Barbara Obermayer-Pietsch Melanie Schweinzer Celine K. Braun Andreas Meinitzer Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction European Journal of Psychotraumatology trimethylamine n-oxide (tmao) acute myocardial infarction gut permeability posttraumatic stress disorder (ptsd) depression biomarker |
| title | Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction |
| title_full | Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction |
| title_fullStr | Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction |
| title_full_unstemmed | Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction |
| title_short | Assessment of trimethylamine N-oxide (TMAO) as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder (PTSD) after acute myocardial infarction |
| title_sort | assessment of trimethylamine n oxide tmao as a potential biomarker of severe stress in patients vulnerable to posttraumatic stress disorder ptsd after acute myocardial infarction |
| topic | trimethylamine n-oxide (tmao) acute myocardial infarction gut permeability posttraumatic stress disorder (ptsd) depression biomarker |
| url | http://dx.doi.org/10.1080/20008198.2021.1920201 |
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