Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review
Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising result...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-07-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/531230 |
| _version_ | 1797745870256472064 |
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| author | Mohammed Abdulagayoom Deena Mudawi Zsolt Lengyel Hayan Abo Samra Awni Alshurafa Mohamed A. Yassin |
| author_facet | Mohammed Abdulagayoom Deena Mudawi Zsolt Lengyel Hayan Abo Samra Awni Alshurafa Mohamed A. Yassin |
| author_sort | Mohammed Abdulagayoom |
| collection | DOAJ |
| description | Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising results in some case reports and a small clinical trial. We present here a fifty-nine-year-old patient with LCH in the lung, liver, and bone who responded well to an imatinib dose of 100 mg daily. Her symptoms improved within 3 months of treatment, and subsequent positron emission tomography-computed tomography (PET/CT) showed resolution of 18F-fluorodeoxyglucose (FDG)-avid lesions. |
| first_indexed | 2024-03-12T15:29:09Z |
| format | Article |
| id | doaj.art-02100bad1edc4d029f330846470ae9da |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-12T15:29:09Z |
| publishDate | 2023-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-02100bad1edc4d029f330846470ae9da2023-08-10T08:11:07ZengKarger PublishersCase Reports in Oncology1662-65752023-07-0116151151810.1159/000531230531230Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature ReviewMohammed Abdulagayoom0https://orcid.org/0000-0003-0622-8455Deena Mudawi1Zsolt Lengyel2Hayan Abo Samra3https://orcid.org/0000-0002-7009-313XAwni Alshurafa4Mohamed A. Yassin5Department of Hematology, National Center for Cancer Care and Research, HMC, Doha, QatarDepartment of Hematology, National Center for Cancer Care and Research, HMC, Doha, QatarDepartment of PET/CT and Nuclear Medicine, HMC, Doha, QatarDepartment of Laboratory Medicine and Pathology, HMC, Doha, QatarDepartment of Hematology, National Center for Cancer Care and Research, HMC, Doha, QatarDepartment of Hematology, National Center for Cancer Care and Research, HMC, Doha, QatarLangerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by infiltration of histiocytes and dendritic cells into body organs. While treatment is better established in pediatrics, there is still no consensus on therapy in the adult population. Imatinib has shown promising results in some case reports and a small clinical trial. We present here a fifty-nine-year-old patient with LCH in the lung, liver, and bone who responded well to an imatinib dose of 100 mg daily. Her symptoms improved within 3 months of treatment, and subsequent positron emission tomography-computed tomography (PET/CT) showed resolution of 18F-fluorodeoxyglucose (FDG)-avid lesions.https://beta.karger.com/Article/FullText/531230histiocytic cell neoplasmsdendritic cell neoplasmshistiocytosistyrosine kinase inhibitorspositron emission tomography scan |
| spellingShingle | Mohammed Abdulagayoom Deena Mudawi Zsolt Lengyel Hayan Abo Samra Awni Alshurafa Mohamed A. Yassin Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review Case Reports in Oncology histiocytic cell neoplasms dendritic cell neoplasms histiocytosis tyrosine kinase inhibitors positron emission tomography scan |
| title | Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review |
| title_full | Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review |
| title_fullStr | Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review |
| title_full_unstemmed | Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review |
| title_short | Langerhans Cell Histiocytosis with Good Response to Low-Dose Imatinib: Case Report and Literature Review |
| title_sort | langerhans cell histiocytosis with good response to low dose imatinib case report and literature review |
| topic | histiocytic cell neoplasms dendritic cell neoplasms histiocytosis tyrosine kinase inhibitors positron emission tomography scan |
| url | https://beta.karger.com/Article/FullText/531230 |
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