KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela
Carbapenems have generally been considered the pharmacotherapy of last resort for managing infections associated with health services caused by multidrug-resistant gram-negative bacteria. However, it is worrisome that this situation is being threatened worldwide with the appearance of bacterial stra...
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| Format: | Article |
| Language: | English |
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2014-08-01
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| Series: | Kasmera |
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| Online Access: | https://produccioncientificaluz.org/index.php/kasmera/article/view/19495 |
| _version_ | 1827837506966519808 |
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| author | Liliana Gómez Gamboa Armindo Perozo Mena Judith Lugo José Bermúdez González Irene Zabala Ever Morales |
| author_facet | Liliana Gómez Gamboa Armindo Perozo Mena Judith Lugo José Bermúdez González Irene Zabala Ever Morales |
| author_sort | Liliana Gómez Gamboa |
| collection | DOAJ |
| description | Carbapenems have generally been considered the pharmacotherapy of last resort for managing infections associated with health services caused by multidrug-resistant gram-negative bacteria. However, it is worrisome that this situation is being threatened worldwide with the appearance of bacterial strains that resist these antibiotics due to the production of novel B-lactamases with direct carbapenem-hydrolyzing activity (carbapenemases). This study was performed to characterize KPC carbapenemase-producing Enterobacteriaceae isolated from a hospital in the Zulia region during 2009-2013 in terms of their geno- and phenotypes. KPC carbapenemase production was detected in 423 strains of carbapenem-resistant Enterobacteriaceae (36.29%). The most affected patients were male adults from the intensive care unit. The most common site of colonization was the respiratory tract, while rectal carrier status was rare. These KPC carbapenemases were detected mainly in K. pneumoniae, K. oxytoca, E.coli and E. cloacae. Most isolates showed multidrug-resistance and an extensively drug-resistant phenotype. The majority of the phenotypic methods were effective for the detection of KPC producers in Enterobacteriaceae isolates and the presence of blaKPC gene confirmed that the Carbapenemase circulating in Enterobacteriaceae strains in this region are the KPC type. |
| first_indexed | 2024-03-12T06:44:47Z |
| format | Article |
| id | doaj.art-0210a34c378c4a1c91035925e71d3ca2 |
| institution | Directory Open Access Journal |
| issn | 0075-5222 2477-9628 |
| language | English |
| last_indexed | 2024-03-12T06:44:47Z |
| publishDate | 2014-08-01 |
| publisher | Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
| record_format | Article |
| series | Kasmera |
| spelling | doaj.art-0210a34c378c4a1c91035925e71d3ca22023-09-03T00:36:55ZengUniversidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y TropicalesKasmera0075-52222477-96282014-08-014228910424381KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, VenezuelaLiliana Gómez Gamboa0Armindo Perozo Mena1Judith Lugo2José Bermúdez González3Irene Zabala4Ever Morales5Unidad Curricular Bacteriología y Virología. Facultad de Medicina. Universidad del Zulia.Unidad Curricular Práctica Profesional de Bacteriología. Facultad de Medicina. Universidad del Zulia.Centro Clínico María Auxiliadora, Coro, Estado FalcónLaboratorio de Bioquímica y Microorganismos Fotosintéticos. Facultad Experimental de Ciencias. Universidad del Zulia.Laboratorio de Genética y Biología Molecular. Facultad Experimental de Ciencias. Universi dad del Zulia.Laboratorio de Bioquímica y Microorganismos Fotosintéticos. Facultad Experimental de Ciencias. Universidad del Zulia.Carbapenems have generally been considered the pharmacotherapy of last resort for managing infections associated with health services caused by multidrug-resistant gram-negative bacteria. However, it is worrisome that this situation is being threatened worldwide with the appearance of bacterial strains that resist these antibiotics due to the production of novel B-lactamases with direct carbapenem-hydrolyzing activity (carbapenemases). This study was performed to characterize KPC carbapenemase-producing Enterobacteriaceae isolated from a hospital in the Zulia region during 2009-2013 in terms of their geno- and phenotypes. KPC carbapenemase production was detected in 423 strains of carbapenem-resistant Enterobacteriaceae (36.29%). The most affected patients were male adults from the intensive care unit. The most common site of colonization was the respiratory tract, while rectal carrier status was rare. These KPC carbapenemases were detected mainly in K. pneumoniae, K. oxytoca, E.coli and E. cloacae. Most isolates showed multidrug-resistance and an extensively drug-resistant phenotype. The majority of the phenotypic methods were effective for the detection of KPC producers in Enterobacteriaceae isolates and the presence of blaKPC gene confirmed that the Carbapenemase circulating in Enterobacteriaceae strains in this region are the KPC type.https://produccioncientificaluz.org/index.php/kasmera/article/view/19495EnterobacteriaceaeCarbapenemasas KPCSusceptibilidadAntibióticos |
| spellingShingle | Liliana Gómez Gamboa Armindo Perozo Mena Judith Lugo José Bermúdez González Irene Zabala Ever Morales KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela Kasmera Enterobacteriaceae Carbapenemasas KPC Susceptibilidad Antibióticos |
| title | KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela |
| title_full | KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela |
| title_fullStr | KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela |
| title_full_unstemmed | KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela |
| title_short | KPC Carbapenemase-producing Enterobacteriaceae isolated in a Maracaibo’s Hospital, Venezuela |
| title_sort | kpc carbapenemase producing enterobacteriaceae isolated in a maracaibo s hospital venezuela |
| topic | Enterobacteriaceae Carbapenemasas KPC Susceptibilidad Antibióticos |
| url | https://produccioncientificaluz.org/index.php/kasmera/article/view/19495 |
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