TRP channels and monoterpenes: Past and current leads on analgesic properties
The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.945450/full |
| _version_ | 1818163505235230720 |
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| author | Hugues Petitjean Eléa Héberlé Louis Hilfiger Louis Hilfiger Olga Łapieś Guillaume Rodrigue Alexandre Charlet |
| author_facet | Hugues Petitjean Eléa Héberlé Louis Hilfiger Louis Hilfiger Olga Łapieś Guillaume Rodrigue Alexandre Charlet |
| author_sort | Hugues Petitjean |
| collection | DOAJ |
| description | The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions. |
| first_indexed | 2024-12-11T16:50:37Z |
| format | Article |
| id | doaj.art-0211f2a32ac149fe8f0899c9ba88a55a |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-11T16:50:37Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-0211f2a32ac149fe8f0899c9ba88a55a2022-12-22T00:58:06ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-07-011510.3389/fnmol.2022.945450945450TRP channels and monoterpenes: Past and current leads on analgesic propertiesHugues Petitjean0Eléa Héberlé1Louis Hilfiger2Louis Hilfiger3Olga Łapieś4Guillaume Rodrigue5Alexandre Charlet6Benephyt, Strasbourg, FranceBenephyt, Strasbourg, FranceBenephyt, Strasbourg, FranceCentre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, FranceCentre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, FranceBenephyt, Strasbourg, FranceCentre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, FranceThe activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions.https://www.frontiersin.org/articles/10.3389/fnmol.2022.945450/fullmonoterpenespaininflammationTRPpulegonementhol |
| spellingShingle | Hugues Petitjean Eléa Héberlé Louis Hilfiger Louis Hilfiger Olga Łapieś Guillaume Rodrigue Alexandre Charlet TRP channels and monoterpenes: Past and current leads on analgesic properties Frontiers in Molecular Neuroscience monoterpenes pain inflammation TRP pulegone menthol |
| title | TRP channels and monoterpenes: Past and current leads on analgesic properties |
| title_full | TRP channels and monoterpenes: Past and current leads on analgesic properties |
| title_fullStr | TRP channels and monoterpenes: Past and current leads on analgesic properties |
| title_full_unstemmed | TRP channels and monoterpenes: Past and current leads on analgesic properties |
| title_short | TRP channels and monoterpenes: Past and current leads on analgesic properties |
| title_sort | trp channels and monoterpenes past and current leads on analgesic properties |
| topic | monoterpenes pain inflammation TRP pulegone menthol |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.945450/full |
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