Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

Abstract Background A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnos...

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Main Authors: Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E. Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J. Giamarellos-Bourboulis, on behalf of the Hellenic Sepsis Study Group
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Medicine
Subjects:
Macrophages
Sepsis
Ferritin
Interleukin-18
Outcome
Online Access:http://link.springer.com/article/10.1186/s12916-017-0930-5

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