Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement
A 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exente...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Medical Mycology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753921000142 |
| _version_ | 1818645412060332032 |
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| author | R.P. Miller L. Farrugia J. Leask K. Khalsa N. Khanna L. Melia |
| author_facet | R.P. Miller L. Farrugia J. Leask K. Khalsa N. Khanna L. Melia |
| author_sort | R.P. Miller |
| collection | DOAJ |
| description | A 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exenteration, accompanied by anti-fungal therapy with liposomal amphotericin B and posaconazole, followed by isavuconazole as salvage therapy. We discuss the challenges around optimising antifungal therapy of this lethal infection in the context of hepatic and renal toxicity. |
| first_indexed | 2024-12-17T00:30:20Z |
| format | Article |
| id | doaj.art-0212a66c49f7489ba3fe0743bc3be33f |
| institution | Directory Open Access Journal |
| issn | 2211-7539 |
| language | English |
| last_indexed | 2024-12-17T00:30:20Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj.art-0212a66c49f7489ba3fe0743bc3be33f2022-12-21T22:10:20ZengElsevierMedical Mycology Case Reports2211-75392021-06-01323942Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridementR.P. Miller0L. Farrugia1J. Leask2K. Khalsa3N. Khanna4L. Melia5Department of Ear, Nose & Throat (ENT) Surgery, Queen Elizabeth University Hospital, Glasgow, UKDepartment of Microbiology, Queen Elizabeth University Hospital, Glasgow, UK; Corresponding author.Depatment of Urology, Queen Elizabeth University Hospital, Glasgow, UKDepartment of Microbiology, Queen Elizabeth University Hospital, Glasgow, UKDepartment of Microbiology, Queen Elizabeth University Hospital, Glasgow, UKDepartment of Ear, Nose & Throat (ENT) Surgery, Queen Elizabeth University Hospital, Glasgow, UKA 61-year old lady with poorly-controlled type 2 diabetes mellitus was diagnosed with rhino-orbital-cerebral mucormycosis following presentation with sinusitis, ophthalmoplegia, proptosis and facial numbness. She was treated successfully with aggressive surgical intervention including orbital exenteration, accompanied by anti-fungal therapy with liposomal amphotericin B and posaconazole, followed by isavuconazole as salvage therapy. We discuss the challenges around optimising antifungal therapy of this lethal infection in the context of hepatic and renal toxicity.http://www.sciencedirect.com/science/article/pii/S2211753921000142Rhino-orbital-cerebral mucormycosisDiabetes mellitusIsavuconazoleRhizopus arrhizus |
| spellingShingle | R.P. Miller L. Farrugia J. Leask K. Khalsa N. Khanna L. Melia Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement Medical Mycology Case Reports Rhino-orbital-cerebral mucormycosis Diabetes mellitus Isavuconazole Rhizopus arrhizus |
| title | Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement |
| title_full | Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement |
| title_fullStr | Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement |
| title_full_unstemmed | Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement |
| title_short | Successful treatment of Rhizopus arrhizus rhino-orbital-cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement |
| title_sort | successful treatment of rhizopus arrhizus rhino orbital cerebral mucormycosis with isavuconazole salvage therapy following extensive debridement |
| topic | Rhino-orbital-cerebral mucormycosis Diabetes mellitus Isavuconazole Rhizopus arrhizus |
| url | http://www.sciencedirect.com/science/article/pii/S2211753921000142 |
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