The critical function of metabolic reprogramming in cancer metastasis
Abstract Cancer metastasis is the leading cause of cancer‐related death. It is a complex, inefficient, and multistep process related to poor prognosis and high mortality of patients. Increasing evidence has shown that metabolic programming is a recognized hallmarker of cancer, plays a critical role...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-03-01
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| Series: | Aging and Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/aac2.12044 |
| _version_ | 1818442206280679424 |
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| author | Sun‐Zhe Xie Jun‐Jie Pan Jian‐Feng Xu Wen‐wei Zhu Lun‐Xiu Qin |
| author_facet | Sun‐Zhe Xie Jun‐Jie Pan Jian‐Feng Xu Wen‐wei Zhu Lun‐Xiu Qin |
| author_sort | Sun‐Zhe Xie |
| collection | DOAJ |
| description | Abstract Cancer metastasis is the leading cause of cancer‐related death. It is a complex, inefficient, and multistep process related to poor prognosis and high mortality of patients. Increasing evidence has shown that metabolic programming is a recognized hallmarker of cancer, plays a critical role in cancer metastasis. Metabolism alterations of glucose, lipid, and amino acid provide cancer cells with energy and substances for biosynthesis, maintain biofunctions and significantly affect proliferation, invasion, and metastasis of cancer cells. Tumor microenvironment (TME) is a complex system formed by varieties of cellular and noncellular elements. Nontumor cells in TME also undergo metabolic reprogramming or respond to metabolites to promote migration and invasion of cancer cells. A comprehensive understanding of the regulatory mechanism in metastasis from the metabolic reprogramming aspect is required to develop new therapeutic strategies combatting cancer metastasis. This review illustrates the metabolic reprogramming and interaction of cancer cells and nontumor cells in the TME, and the development of treatment strategies targeting metabolism alterations. |
| first_indexed | 2024-12-14T18:40:27Z |
| format | Article |
| id | doaj.art-021300ff723241c6a5ebf6133f7228c6 |
| institution | Directory Open Access Journal |
| issn | 2643-8909 |
| language | English |
| last_indexed | 2024-12-14T18:40:27Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aging and Cancer |
| spelling | doaj.art-021300ff723241c6a5ebf6133f7228c62022-12-21T22:51:29ZengWileyAging and Cancer2643-89092022-03-0131204310.1002/aac2.12044The critical function of metabolic reprogramming in cancer metastasisSun‐Zhe Xie0Jun‐Jie Pan1Jian‐Feng Xu2Wen‐wei Zhu3Lun‐Xiu Qin4Department of General Surgery Huashan Hospital, Fudan University Shanghai ChinaDepartment of General Surgery Huashan Hospital, Fudan University Shanghai ChinaDepartment of General Surgery Huashan Hospital, Fudan University Shanghai ChinaDepartment of General Surgery Huashan Hospital, Fudan University Shanghai ChinaDepartment of General Surgery Huashan Hospital, Fudan University Shanghai ChinaAbstract Cancer metastasis is the leading cause of cancer‐related death. It is a complex, inefficient, and multistep process related to poor prognosis and high mortality of patients. Increasing evidence has shown that metabolic programming is a recognized hallmarker of cancer, plays a critical role in cancer metastasis. Metabolism alterations of glucose, lipid, and amino acid provide cancer cells with energy and substances for biosynthesis, maintain biofunctions and significantly affect proliferation, invasion, and metastasis of cancer cells. Tumor microenvironment (TME) is a complex system formed by varieties of cellular and noncellular elements. Nontumor cells in TME also undergo metabolic reprogramming or respond to metabolites to promote migration and invasion of cancer cells. A comprehensive understanding of the regulatory mechanism in metastasis from the metabolic reprogramming aspect is required to develop new therapeutic strategies combatting cancer metastasis. This review illustrates the metabolic reprogramming and interaction of cancer cells and nontumor cells in the TME, and the development of treatment strategies targeting metabolism alterations.https://doi.org/10.1002/aac2.12044cancer metastasisimmune cellsmetabolic reprogrammingtumor microenvironmentWarburg effect |
| spellingShingle | Sun‐Zhe Xie Jun‐Jie Pan Jian‐Feng Xu Wen‐wei Zhu Lun‐Xiu Qin The critical function of metabolic reprogramming in cancer metastasis Aging and Cancer cancer metastasis immune cells metabolic reprogramming tumor microenvironment Warburg effect |
| title | The critical function of metabolic reprogramming in cancer metastasis |
| title_full | The critical function of metabolic reprogramming in cancer metastasis |
| title_fullStr | The critical function of metabolic reprogramming in cancer metastasis |
| title_full_unstemmed | The critical function of metabolic reprogramming in cancer metastasis |
| title_short | The critical function of metabolic reprogramming in cancer metastasis |
| title_sort | critical function of metabolic reprogramming in cancer metastasis |
| topic | cancer metastasis immune cells metabolic reprogramming tumor microenvironment Warburg effect |
| url | https://doi.org/10.1002/aac2.12044 |
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