The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration

Here, we report the in vitro characterization of the P2Y12 receptor antagonist selatogrel (ACT-246475). Binding studies with radiolabeled selatogrel demonstrated that selatogrel is a competitive antagonist of ADP binding to the P2Y12 receptor with a fast onset of action. Consequently, selatogrel was...

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Bibliographic Details
Main Authors: Martine Baumann, Benoît Lack, Isabelle Guillaumat, Mark J. Murphy, Markus A. Riederer
Format: Article
Language:English
Published: Taylor & Francis Group 2022-01-01
Series:Platelets
Subjects:
p2y12 receptor antagonist
platelet aggregation
platelet inhibition
Online Access:http://dx.doi.org/10.1080/09537104.2020.1869711

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