Evolutionary Origin of Human <i>PALB2</i> Germline Pathogenic Variants

Evolutionary Origin of Human <i>PALB2</i> Germline Pathogenic Variants

<i>PALB2</i> (Partner and localizer of BRCA2) is crucial for repairing DNA double-stranded breaks (DSBs) through homologous recombination (HR). Germline pathogenic variation in <i>PALB2</i> disrupts DNA damage repair and increases the risk of Fanconi Anemia, breast cancer, an...

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Bibliographic Details
Main Authors: Jia Sheng Chian, Jiaheng Li, San Ming Wang
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>PALB2</i>
evolutionary origin
phylogenetic
paleoanthropology
Online Access:https://www.mdpi.com/1422-0067/24/14/11343

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