APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS
There are results of the possibility of applying a chromatographic column Zorbax NH2 150х4,6 mm (5 µm) to separate the esters of 4-hydroxybenzoic acid (parabens). Separation of test compounds on the column with aminosorbents in hydrophilic interaction chromatography is possible at a content of more...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/321 |
| _version_ | 1797875002410795008 |
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| author | A. S. Osipov O. A. Popova A. I. Sulimenkova M. V. Nezdolieva |
| author_facet | A. S. Osipov O. A. Popova A. I. Sulimenkova M. V. Nezdolieva |
| author_sort | A. S. Osipov |
| collection | DOAJ |
| description | There are results of the possibility of applying a chromatographic column Zorbax NH2 150х4,6 mm (5 µm) to separate the esters of 4-hydroxybenzoic acid (parabens). Separation of test compounds on the column with aminosorbents in hydrophilic interaction chromatography is possible at a content of more than 95% of acetonitrile in the mobile phase. The resolution between peaks of parabens in a hydrophilic interaction liquid chromatography is substantially less than in a reverse-phase chromatography. In contrast to the amino nitrile groups Zorbax XDB CN columns practically haven’t affinity for the phenolic hydroxyl groups of parabens in a hydrophilic interaction liquid chromatography. Chromatography column Zorbax NH2 can be used to detect a normalized impurity in paraben - 4-hydroxybenzoic acid [mobile phase: acetonitrile - 1% acetic acid in water (80:20)]. |
| first_indexed | 2024-04-10T01:40:52Z |
| format | Article |
| id | doaj.art-02193b9cea704455a6a9a5151c25c8dc |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:52Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-02193b9cea704455a6a9a5151c25c8dc2023-03-13T09:13:58ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0101104107321APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSISA. S. Osipov0O. A. Popova1A. I. Sulimenkova2M. V. Nezdolieva3ФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииФГБУ «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииThere are results of the possibility of applying a chromatographic column Zorbax NH2 150х4,6 mm (5 µm) to separate the esters of 4-hydroxybenzoic acid (parabens). Separation of test compounds on the column with aminosorbents in hydrophilic interaction chromatography is possible at a content of more than 95% of acetonitrile in the mobile phase. The resolution between peaks of parabens in a hydrophilic interaction liquid chromatography is substantially less than in a reverse-phase chromatography. In contrast to the amino nitrile groups Zorbax XDB CN columns practically haven’t affinity for the phenolic hydroxyl groups of parabens in a hydrophilic interaction liquid chromatography. Chromatography column Zorbax NH2 can be used to detect a normalized impurity in paraben - 4-hydroxybenzoic acid [mobile phase: acetonitrile - 1% acetic acid in water (80:20)].https://www.pharmjournal.ru/jour/article/view/321вэжхжидкостная хроматография гидрофильных взаимодействийэфиры 4-гидроксибензойной кислоты (парабены)фармакопея сшаевропейская фармакопея |
| spellingShingle | A. S. Osipov O. A. Popova A. I. Sulimenkova M. V. Nezdolieva APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS Разработка и регистрация лекарственных средств вэжх жидкостная хроматография гидрофильных взаимодействий эфиры 4-гидроксибензойной кислоты (парабены) фармакопея сша европейская фармакопея |
| title | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS |
| title_full | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS |
| title_fullStr | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS |
| title_full_unstemmed | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS |
| title_short | APPLICATION OF HYDROPHYILIC INTERACTIONS LIQUID CHROMATOGRAPHY FOR PARABENS ANALYSIS |
| title_sort | application of hydrophyilic interactions liquid chromatography for parabens analysis |
| topic | вэжх жидкостная хроматография гидрофильных взаимодействий эфиры 4-гидроксибензойной кислоты (парабены) фармакопея сша европейская фармакопея |
| url | https://www.pharmjournal.ru/jour/article/view/321 |
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