Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital
Background and objective. The prevalence of mild neurocognitive Disorder (MND) has increased after using antiretroviral therapy (ARV), which is around 51.5%. Inflammation plays an essential role in the neurodegenerative state of HIV patients. Peripheral blood images can assess increased macrophage a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2023-09-01
|
| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-03.pdf |
| _version_ | 1827380821485420544 |
|---|---|
| author | Ketut Widyastuti I Made Susila Utama Anak Agung Ayu Putri Laksmidewi |
| author_facet | Ketut Widyastuti I Made Susila Utama Anak Agung Ayu Putri Laksmidewi |
| author_sort | Ketut Widyastuti |
| collection | DOAJ |
| description | Background and objective. The prevalence of mild neurocognitive Disorder (MND) has increased after using antiretroviral therapy (ARV), which is around 51.5%. Inflammation plays an essential role in the neurodegenerative state of HIV patients. Peripheral blood images can assess increased macrophage activation by evaluating the number of leukocytes, neutrophils, total lymphocytes, hemoglobin, platelets, platelets, and neutrophil-lymphocyte ratio (NLR) to determine the condition of systemic inflammation in HIV patients with cognitive impairment. This study to know differences in the appearance of peripheral blood in HIV patients with and without cognitive impairment.
Method. Observational analytic study with a cross-sectional design on 44 HIV patients who were outpatients at the polyclinic Voluntary Counseling and Testing (VCT) at Prof Dr. IGNG Ngoerah Denpasar Hospital. Subjects were divided into 2 groups based on cognitive status assessed using the MoCA-INA questionnaire. The peripheral blood images considered were the average levels of leukocytes, neutrophils, lymphocytes, hemoglobin, hematocrit, platelets, and the ratio of neutrophils to lymphocytes. Results. 31-40 years old, male, with >9 years of education, has a CD4 count >200, and has received ARV therapy >1 year.
The Shapiro-Wilk normality test performed on both groups showed that the data were normally distributed with p>0.05. Bivariate analysis using an independent t-test with a 95% confidence level (α=0.05) found significant differences in mean
leukocyte, neutrophil, lymphocyte, and neutrophil-lymphocyte ratios (p<0.05) between groups of HIV patients with cognitive impairment and no cognitive impairment. Conclusion. Inflammatory markers from the peripheral blood picture are increased in HIV-infected persons. |
| first_indexed | 2024-03-08T13:39:51Z |
| format | Article |
| id | doaj.art-0219f770a01d4716a61374d5bd467de1 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-03-08T13:39:51Z |
| publishDate | 2023-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-0219f770a01d4716a61374d5bd467de12024-01-16T10:51:08ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942023-09-0122319119510.37897/RJN.2023.3.3Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” HospitalKetut Widyastuti0I Made Susila Utama1Anak Agung Ayu Putri Laksmidewi2Department of Neurology, Faculty of Medicine, Udayana University, Bali, Indonesia Department of Internal Medicine, Faculty of Medicine Udayana University, Bali, IndonesiaDepartment of Neurology, Faculty of Medicine, Udayana University, Bali, IndonesiaBackground and objective. The prevalence of mild neurocognitive Disorder (MND) has increased after using antiretroviral therapy (ARV), which is around 51.5%. Inflammation plays an essential role in the neurodegenerative state of HIV patients. Peripheral blood images can assess increased macrophage activation by evaluating the number of leukocytes, neutrophils, total lymphocytes, hemoglobin, platelets, platelets, and neutrophil-lymphocyte ratio (NLR) to determine the condition of systemic inflammation in HIV patients with cognitive impairment. This study to know differences in the appearance of peripheral blood in HIV patients with and without cognitive impairment. Method. Observational analytic study with a cross-sectional design on 44 HIV patients who were outpatients at the polyclinic Voluntary Counseling and Testing (VCT) at Prof Dr. IGNG Ngoerah Denpasar Hospital. Subjects were divided into 2 groups based on cognitive status assessed using the MoCA-INA questionnaire. The peripheral blood images considered were the average levels of leukocytes, neutrophils, lymphocytes, hemoglobin, hematocrit, platelets, and the ratio of neutrophils to lymphocytes. Results. 31-40 years old, male, with >9 years of education, has a CD4 count >200, and has received ARV therapy >1 year. The Shapiro-Wilk normality test performed on both groups showed that the data were normally distributed with p>0.05. Bivariate analysis using an independent t-test with a 95% confidence level (α=0.05) found significant differences in mean leukocyte, neutrophil, lymphocyte, and neutrophil-lymphocyte ratios (p<0.05) between groups of HIV patients with cognitive impairment and no cognitive impairment. Conclusion. Inflammatory markers from the peripheral blood picture are increased in HIV-infected persons.https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-03.pdfperipheral bloodneutrophilslymphocytescognitivehivmoca-ina |
| spellingShingle | Ketut Widyastuti I Made Susila Utama Anak Agung Ayu Putri Laksmidewi Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital Romanian Journal of Neurology peripheral blood neutrophils lymphocytes cognitive hiv moca-ina |
| title | Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital |
| title_full | Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital |
| title_fullStr | Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital |
| title_full_unstemmed | Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital |
| title_short | Differences peripheral of blood in HIV patients with and without cognitive disorders at “Prof. Dr. IGNG Ngoerah” Hospital |
| title_sort | differences peripheral of blood in hiv patients with and without cognitive disorders at prof dr igng ngoerah hospital |
| topic | peripheral blood neutrophils lymphocytes cognitive hiv moca-ina |
| url | https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-03.pdf |
| work_keys_str_mv | AT ketutwidyastuti differencesperipheralofbloodinhivpatientswithandwithoutcognitivedisordersatprofdrigngngoerahhospital AT imadesusilautama differencesperipheralofbloodinhivpatientswithandwithoutcognitivedisordersatprofdrigngngoerahhospital AT anakagungayuputrilaksmidewi differencesperipheralofbloodinhivpatientswithandwithoutcognitivedisordersatprofdrigngngoerahhospital |