Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults
Transcranial direct-current stimulation (tDCS) is a form of non-invasive brain stimulation that induces electric fields in neuronal tissue, modulating cortical excitability. Therapeutic applications of tDCS are rapidly expanding, and are being investigated in pediatrics for various clinical conditio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2018.00268/full |
| _version_ | 1818543590618431488 |
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| author | Patrick Ciechanski Patrick Ciechanski Helen L. Carlson Sabrina S. Yu Adam Kirton Adam Kirton |
| author_facet | Patrick Ciechanski Patrick Ciechanski Helen L. Carlson Sabrina S. Yu Adam Kirton Adam Kirton |
| author_sort | Patrick Ciechanski |
| collection | DOAJ |
| description | Transcranial direct-current stimulation (tDCS) is a form of non-invasive brain stimulation that induces electric fields in neuronal tissue, modulating cortical excitability. Therapeutic applications of tDCS are rapidly expanding, and are being investigated in pediatrics for various clinical conditions. Anatomical variations are among a host of factors that influence the effects of tDCS, and pronounced anatomical differences between children and adults suggest that induced electric fields may be substantially different across development. The aim of this study was to determine the strength and distribution of tDCS-induced electric fields across development. Typically developing children, adolescents, and adults were recruited. Individualized finite-element method modeling of primary motor cortex (M1) targeting tDCS was performed. In the largest pediatric sample to date, we found significantly higher peak and mean M1 electric field strength, and more expansive electric field spread for children compared to adults. Electric fields were often comparable between adolescents and adults. Our results suggest that these differences may be associated with age-related differences in skull and extra-axial space thickness, as well as developmental changes occurring in gray and white matter. Individualized current modeling may be a valuable tool for personalizing effective doses of tDCS in future pediatric clinical trials. |
| first_indexed | 2024-12-11T22:37:24Z |
| format | Article |
| id | doaj.art-021a106728074ba887e74ad5a64a7056 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T22:37:24Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-021a106728074ba887e74ad5a64a70562022-12-22T00:47:55ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-07-011210.3389/fnhum.2018.00268367552Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and AdultsPatrick Ciechanski0Patrick Ciechanski1Helen L. Carlson2Sabrina S. Yu3Adam Kirton4Adam Kirton5Calgary Pediatric Stroke Program, University of Calgary, Calgary, AB, CanadaDepartment of Neurosciences, University of Calgary, Calgary, AB, CanadaCalgary Pediatric Stroke Program, University of Calgary, Calgary, AB, CanadaCalgary Pediatric Stroke Program, University of Calgary, Calgary, AB, CanadaCalgary Pediatric Stroke Program, University of Calgary, Calgary, AB, CanadaDepartments of Pediatrics and Clinical Neurosciences, University of Calgary, Calgary, AB, CanadaTranscranial direct-current stimulation (tDCS) is a form of non-invasive brain stimulation that induces electric fields in neuronal tissue, modulating cortical excitability. Therapeutic applications of tDCS are rapidly expanding, and are being investigated in pediatrics for various clinical conditions. Anatomical variations are among a host of factors that influence the effects of tDCS, and pronounced anatomical differences between children and adults suggest that induced electric fields may be substantially different across development. The aim of this study was to determine the strength and distribution of tDCS-induced electric fields across development. Typically developing children, adolescents, and adults were recruited. Individualized finite-element method modeling of primary motor cortex (M1) targeting tDCS was performed. In the largest pediatric sample to date, we found significantly higher peak and mean M1 electric field strength, and more expansive electric field spread for children compared to adults. Electric fields were often comparable between adolescents and adults. Our results suggest that these differences may be associated with age-related differences in skull and extra-axial space thickness, as well as developmental changes occurring in gray and white matter. Individualized current modeling may be a valuable tool for personalizing effective doses of tDCS in future pediatric clinical trials.https://www.frontiersin.org/article/10.3389/fnhum.2018.00268/fullcurrent modelingtDCSmotorpediatricsFEMchildren |
| spellingShingle | Patrick Ciechanski Patrick Ciechanski Helen L. Carlson Sabrina S. Yu Adam Kirton Adam Kirton Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults Frontiers in Human Neuroscience current modeling tDCS motor pediatrics FEM children |
| title | Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults |
| title_full | Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults |
| title_fullStr | Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults |
| title_full_unstemmed | Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults |
| title_short | Modeling Transcranial Direct-Current Stimulation-Induced Electric Fields in Children and Adults |
| title_sort | modeling transcranial direct current stimulation induced electric fields in children and adults |
| topic | current modeling tDCS motor pediatrics FEM children |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2018.00268/full |
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