The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology
Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6364 |
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| author | Ljuba C. Ponomarev Jakub Ksiazkiewicz Michael W. Staring Aernout Luttun An Zwijsen |
| author_facet | Ljuba C. Ponomarev Jakub Ksiazkiewicz Michael W. Staring Aernout Luttun An Zwijsen |
| author_sort | Ljuba C. Ponomarev |
| collection | DOAJ |
| description | Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in vascular signaling. Indeed, mutations in genes encoding different components of the BMP pathway cause various severe vascular diseases. Their signaling contributes to the morphological, functional and molecular heterogeneity among endothelial cells in different vessel types such as arteries, veins, lymphatic vessels and capillaries within different organs. The BMP pathway is a remarkably fine-tuned pathway. As a result, its signaling output in the vessel wall critically depends on the cellular context, which includes flow hemodynamics, interplay with other vascular signaling cascades and the interaction of endothelial cells with peri-endothelial cells and the surrounding matrix. In this review, the emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature. |
| first_indexed | 2024-03-10T10:24:59Z |
| format | Article |
| id | doaj.art-021a9f06e1784690a854a79db2e36450 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:24:59Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-021a9f06e1784690a854a79db2e364502023-11-22T00:04:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212636410.3390/ijms22126364The BMP Pathway in Blood Vessel and Lymphatic Vessel BiologyLjuba C. Ponomarev0Jakub Ksiazkiewicz1Michael W. Staring2Aernout Luttun3An Zwijsen4Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, BelgiumDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, BelgiumDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, BelgiumDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, BelgiumDepartment of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, BelgiumBone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in vascular signaling. Indeed, mutations in genes encoding different components of the BMP pathway cause various severe vascular diseases. Their signaling contributes to the morphological, functional and molecular heterogeneity among endothelial cells in different vessel types such as arteries, veins, lymphatic vessels and capillaries within different organs. The BMP pathway is a remarkably fine-tuned pathway. As a result, its signaling output in the vessel wall critically depends on the cellular context, which includes flow hemodynamics, interplay with other vascular signaling cascades and the interaction of endothelial cells with peri-endothelial cells and the surrounding matrix. In this review, the emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.https://www.mdpi.com/1422-0067/22/12/6364BMPBMP pathway fine-tuninglymphatic vessel biologymechano-transductionvascular malformationssignaling cross-talk |
| spellingShingle | Ljuba C. Ponomarev Jakub Ksiazkiewicz Michael W. Staring Aernout Luttun An Zwijsen The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology International Journal of Molecular Sciences BMP BMP pathway fine-tuning lymphatic vessel biology mechano-transduction vascular malformations signaling cross-talk |
| title | The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology |
| title_full | The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology |
| title_fullStr | The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology |
| title_full_unstemmed | The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology |
| title_short | The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology |
| title_sort | bmp pathway in blood vessel and lymphatic vessel biology |
| topic | BMP BMP pathway fine-tuning lymphatic vessel biology mechano-transduction vascular malformations signaling cross-talk |
| url | https://www.mdpi.com/1422-0067/22/12/6364 |
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