Exogenic and endogenic factors in chronic obstructive pulmonary disease forming
To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2003-03-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3854 |
| _version_ | 1797873349167153152 |
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| author | E. B. Bukreeva S. A. Bogushevich E. A. Dementieva G. E. Chernogoryuk S. V. Nesterovich G. N. Seitova S. V. Buikin |
| author_facet | E. B. Bukreeva S. A. Bogushevich E. A. Dementieva G. E. Chernogoryuk S. V. Nesterovich G. N. Seitova S. V. Buikin |
| author_sort | E. B. Bukreeva |
| collection | DOAJ |
| description | To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary. |
| first_indexed | 2024-04-10T01:14:46Z |
| format | Article |
| id | doaj.art-021b8071d3014ccb89598c87b6bbc647 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:14:46Z |
| publishDate | 2003-03-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-021b8071d3014ccb89598c87b6bbc6472023-03-13T09:58:01ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842003-03-0121757710.20538/1682-0363-2003-1-75-772461Exogenic and endogenic factors in chronic obstructive pulmonary disease formingE. B. Bukreeva0S. A. Bogushevich1E. A. Dementieva2G. E. Chernogoryuk3S. V. Nesterovich4G. N. Seitova5S. V. Buikin6Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетTo determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.https://bulletin.ssmu.ru/jour/article/view/3854хоблкурениеполлютантыполиморфизм гена ά1-пи |
| spellingShingle | E. B. Bukreeva S. A. Bogushevich E. A. Dementieva G. E. Chernogoryuk S. V. Nesterovich G. N. Seitova S. V. Buikin Exogenic and endogenic factors in chronic obstructive pulmonary disease forming Бюллетень сибирской медицины хобл курение поллютанты полиморфизм гена ά1-пи |
| title | Exogenic and endogenic factors in chronic obstructive pulmonary disease forming |
| title_full | Exogenic and endogenic factors in chronic obstructive pulmonary disease forming |
| title_fullStr | Exogenic and endogenic factors in chronic obstructive pulmonary disease forming |
| title_full_unstemmed | Exogenic and endogenic factors in chronic obstructive pulmonary disease forming |
| title_short | Exogenic and endogenic factors in chronic obstructive pulmonary disease forming |
| title_sort | exogenic and endogenic factors in chronic obstructive pulmonary disease forming |
| topic | хобл курение поллютанты полиморфизм гена ά1-пи |
| url | https://bulletin.ssmu.ru/jour/article/view/3854 |
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