2D-nanomaterials for AKI treatment
Acute kidney injury has always been considered a sword of Damocles over hospitalized patients and has received increasing attention due to its high morbidity, elevated mortality, and poor prognosis. Hence, AKI has a serious detrimental impact not only on the patients, but also on the whole society a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1159989/full |
| _version_ | 1797844637163978752 |
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| author | Qiaohui Chen Qiaohui Chen Xiaoyuan Wang Xiaoyuan Wang Chao Yuan Chao Yuan Yayun Nan Qiong Huang Qiong Huang Kelong Ai Kelong Ai |
| author_facet | Qiaohui Chen Qiaohui Chen Xiaoyuan Wang Xiaoyuan Wang Chao Yuan Chao Yuan Yayun Nan Qiong Huang Qiong Huang Kelong Ai Kelong Ai |
| author_sort | Qiaohui Chen |
| collection | DOAJ |
| description | Acute kidney injury has always been considered a sword of Damocles over hospitalized patients and has received increasing attention due to its high morbidity, elevated mortality, and poor prognosis. Hence, AKI has a serious detrimental impact not only on the patients, but also on the whole society and the associated health insurance systems. Redox imbalance caused by bursts of reactive oxygen species at the renal tubules is the key cause of the structural and functional impairment of the kidney during AKI. Unfortunately, the failure of conventional antioxidant drugs complicates the clinical management of AKI, which is limited to mild supportive therapies. Nanotechnology-mediated antioxidant therapies represent a promising strategy for AKI management. In recent years, two-dimensional (2D) nanomaterials, a new subtype of nanomaterials with ultrathin layer structure, have shown significant advantages in AKI therapy owing to their ultrathin structure, large specific surface area, and unique kidney targeting. Herein, we review recent progress in the development of various 2D nanomaterials for AKI therapy, including DNA origami, germanene, and MXene; moreover, we discuss current opportunities and future challenges in the field, aiming to provide new insights and theoretical support for the development of novel 2D nanomaterials for AKI treatment. |
| first_indexed | 2024-04-09T17:25:32Z |
| format | Article |
| id | doaj.art-021f6b6f1c314bb9b74b8f2b3067fc56 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-09T17:25:32Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-021f6b6f1c314bb9b74b8f2b3067fc562023-04-18T13:32:28ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.115998911599892D-nanomaterials for AKI treatmentQiaohui Chen0Qiaohui Chen1Xiaoyuan Wang2Xiaoyuan Wang3Chao Yuan4Chao Yuan5Yayun Nan6Qiong Huang7Qiong Huang8Kelong Ai9Kelong Ai10Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaGeriatric Medical Center, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, ChinaAcute kidney injury has always been considered a sword of Damocles over hospitalized patients and has received increasing attention due to its high morbidity, elevated mortality, and poor prognosis. Hence, AKI has a serious detrimental impact not only on the patients, but also on the whole society and the associated health insurance systems. Redox imbalance caused by bursts of reactive oxygen species at the renal tubules is the key cause of the structural and functional impairment of the kidney during AKI. Unfortunately, the failure of conventional antioxidant drugs complicates the clinical management of AKI, which is limited to mild supportive therapies. Nanotechnology-mediated antioxidant therapies represent a promising strategy for AKI management. In recent years, two-dimensional (2D) nanomaterials, a new subtype of nanomaterials with ultrathin layer structure, have shown significant advantages in AKI therapy owing to their ultrathin structure, large specific surface area, and unique kidney targeting. Herein, we review recent progress in the development of various 2D nanomaterials for AKI therapy, including DNA origami, germanene, and MXene; moreover, we discuss current opportunities and future challenges in the field, aiming to provide new insights and theoretical support for the development of novel 2D nanomaterials for AKI treatment.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1159989/fulltwo-dimensionnanomaterialstargeted therapyacute kidney injuryantioxidant therapy |
| spellingShingle | Qiaohui Chen Qiaohui Chen Xiaoyuan Wang Xiaoyuan Wang Chao Yuan Chao Yuan Yayun Nan Qiong Huang Qiong Huang Kelong Ai Kelong Ai 2D-nanomaterials for AKI treatment Frontiers in Bioengineering and Biotechnology two-dimension nanomaterials targeted therapy acute kidney injury antioxidant therapy |
| title | 2D-nanomaterials for AKI treatment |
| title_full | 2D-nanomaterials for AKI treatment |
| title_fullStr | 2D-nanomaterials for AKI treatment |
| title_full_unstemmed | 2D-nanomaterials for AKI treatment |
| title_short | 2D-nanomaterials for AKI treatment |
| title_sort | 2d nanomaterials for aki treatment |
| topic | two-dimension nanomaterials targeted therapy acute kidney injury antioxidant therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1159989/full |
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