Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern
Abstract Background Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contribution to systemic concentrations of adipokines. However, proximity of EAT t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12967-019-2060-7 |
| _version_ | 1818039467854790656 |
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| author | Kacper Toczylowski Tomasz Hirnle Dorota Harasiuk Piotr Zabielski Anna Lewczuk Iwona Dmitruk Monika Ksiazek Artur Sulik Jan Gorski Adrian Chabowski Marcin Baranowski |
| author_facet | Kacper Toczylowski Tomasz Hirnle Dorota Harasiuk Piotr Zabielski Anna Lewczuk Iwona Dmitruk Monika Ksiazek Artur Sulik Jan Gorski Adrian Chabowski Marcin Baranowski |
| author_sort | Kacper Toczylowski |
| collection | DOAJ |
| description | Abstract Background Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contribution to systemic concentrations of adipokines. However, proximity of EAT to cardiac muscle and coronary arteries allows cells and proteins to penetrate between tissues. It is hypothesized that overexpression of proinflammatory cytokines in EAT plays an important role in pathophysiology of the heart. The aim of the study was to analyze the relationship between echocardiographic heart parameters and adipokines in plasma, epicardial, and subcutaneous fat in patients with obesity and type 2 diabetes mellitus (T2DM). Additionally, we evaluate proinflammatory properties of EAT by comparing that depot with subcutaneous adipose tissue. Methods The study included 55 male individuals diagnosed with coronary artery disease (CAD) who underwent planned coronary artery bypass graft. Plasma concentrations of leptin, adiponectin, resistin, visfatin, apelin, IL-6, and TNF-α, as well as their mRNA and protein expressions in EAT and subcutaneous adipose tissue (SAT) were determined. Results Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT. Impaired left ventricular (LV) diastolic function was associated with increased plasma concentrations of leptin, resistin, IL-6, and adiponectin, as well as with increased expressions of resistin, apelin, and adiponectin in SAT, and leptin in EAT. Conclusions Obesity and T2DM in individuals with CAD have a limited effect on adipokines. Expression of adipokines in EAT and SAT is linked to certain heart parameters, however diastolic dysfunction of the LV is strongly associated with circulating adipokines. |
| first_indexed | 2024-12-10T07:59:06Z |
| format | Article |
| id | doaj.art-021fb97085e549cb9cb651d42d29b10e |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-10T07:59:06Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-021fb97085e549cb9cb651d42d29b10e2022-12-22T01:56:49ZengBMCJournal of Translational Medicine1479-58762019-09-0117111110.1186/s12967-019-2060-7Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling patternKacper Toczylowski0Tomasz Hirnle1Dorota Harasiuk2Piotr Zabielski3Anna Lewczuk4Iwona Dmitruk5Monika Ksiazek6Artur Sulik7Jan Gorski8Adrian Chabowski9Marcin Baranowski10Department of Pediatric Infectious Diseases, Medical University of BialystokDepartment of Cardiac Surgery, Medical University of BialystokDepartment of Physiology, Medical University of BialystokDepartment of Physiology, Medical University of BialystokDepartment of Cardiac Surgery, Medical University of BialystokDepartment of Cardiac Surgery, Medical University of BialystokDepartment of Physiology, Medical University of BialystokDepartment of Pediatric Infectious Diseases, Medical University of BialystokDepartment of Physiology, Medical University of BialystokDepartment of Physiology, Medical University of BialystokDepartment of Physiology, Medical University of BialystokAbstract Background Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat depot, probably does not make an important contribution to systemic concentrations of adipokines. However, proximity of EAT to cardiac muscle and coronary arteries allows cells and proteins to penetrate between tissues. It is hypothesized that overexpression of proinflammatory cytokines in EAT plays an important role in pathophysiology of the heart. The aim of the study was to analyze the relationship between echocardiographic heart parameters and adipokines in plasma, epicardial, and subcutaneous fat in patients with obesity and type 2 diabetes mellitus (T2DM). Additionally, we evaluate proinflammatory properties of EAT by comparing that depot with subcutaneous adipose tissue. Methods The study included 55 male individuals diagnosed with coronary artery disease (CAD) who underwent planned coronary artery bypass graft. Plasma concentrations of leptin, adiponectin, resistin, visfatin, apelin, IL-6, and TNF-α, as well as their mRNA and protein expressions in EAT and subcutaneous adipose tissue (SAT) were determined. Results Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT. Impaired left ventricular (LV) diastolic function was associated with increased plasma concentrations of leptin, resistin, IL-6, and adiponectin, as well as with increased expressions of resistin, apelin, and adiponectin in SAT, and leptin in EAT. Conclusions Obesity and T2DM in individuals with CAD have a limited effect on adipokines. Expression of adipokines in EAT and SAT is linked to certain heart parameters, however diastolic dysfunction of the LV is strongly associated with circulating adipokines.http://link.springer.com/article/10.1186/s12967-019-2060-7Epicardial adipose tissueObesityType 2 diabetes mellitusHeart failureAdipokinesLeptin |
| spellingShingle | Kacper Toczylowski Tomasz Hirnle Dorota Harasiuk Piotr Zabielski Anna Lewczuk Iwona Dmitruk Monika Ksiazek Artur Sulik Jan Gorski Adrian Chabowski Marcin Baranowski Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern Journal of Translational Medicine Epicardial adipose tissue Obesity Type 2 diabetes mellitus Heart failure Adipokines Leptin |
| title | Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern |
| title_full | Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern |
| title_fullStr | Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern |
| title_full_unstemmed | Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern |
| title_short | Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern |
| title_sort | plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern |
| topic | Epicardial adipose tissue Obesity Type 2 diabetes mellitus Heart failure Adipokines Leptin |
| url | http://link.springer.com/article/10.1186/s12967-019-2060-7 |
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