Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization

Hyperpolarized metabolic contrast agents for magnetic resonance imaging can provide non-invasive and realtime information on tissue specific aberrant metabolism, but producing and handling them is highly demanding because of their short lifetime. Here a solid sample extraction, storage, and transpor...

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Main Authors: Andrea Capozzi, Jan Kilund, Magnus Karlsson, Saket Patel, Arthur Cesar Pinon, François Vibert, Olivier Ouari, Mathilde H. Lerche, Jan Henrik Ardenkjær-Larsen
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-021-00536-9
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author Andrea Capozzi
Jan Kilund
Magnus Karlsson
Saket Patel
Arthur Cesar Pinon
François Vibert
Olivier Ouari
Mathilde H. Lerche
Jan Henrik Ardenkjær-Larsen
author_facet Andrea Capozzi
Jan Kilund
Magnus Karlsson
Saket Patel
Arthur Cesar Pinon
François Vibert
Olivier Ouari
Mathilde H. Lerche
Jan Henrik Ardenkjær-Larsen
author_sort Andrea Capozzi
collection DOAJ
description Hyperpolarized metabolic contrast agents for magnetic resonance imaging can provide non-invasive and realtime information on tissue specific aberrant metabolism, but producing and handling them is highly demanding because of their short lifetime. Here a solid sample extraction, storage, and transport technique allows disconnecting production from end-user sites handling, as well as hour-long lifetimes of the agents.
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spelling doaj.art-02205f4eb13a4a5196a0a6fb9e88e4412022-12-21T23:09:52ZengNature PortfolioCommunications Chemistry2399-36692021-06-014111110.1038/s42004-021-00536-9Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarizationAndrea Capozzi0Jan Kilund1Magnus Karlsson2Saket Patel3Arthur Cesar Pinon4François Vibert5Olivier Ouari6Mathilde H. Lerche7Jan Henrik Ardenkjær-Larsen8LIFMET, Department of Physics, EPFL, Station 6 (Batiment CH)HYPERMAG, Department of Health Technology, Technical University of DenmarkHYPERMAG, Department of Health Technology, Technical University of DenmarkHYPERMAG, Department of Health Technology, Technical University of DenmarkHYPERMAG, Department of Health Technology, Technical University of DenmarkInstitut de Chimie Radicalire Aix-Marseille Université, CNRS, ICR UMR 7273Institut de Chimie Radicalire Aix-Marseille Université, CNRS, ICR UMR 7273HYPERMAG, Department of Health Technology, Technical University of DenmarkHYPERMAG, Department of Health Technology, Technical University of DenmarkHyperpolarized metabolic contrast agents for magnetic resonance imaging can provide non-invasive and realtime information on tissue specific aberrant metabolism, but producing and handling them is highly demanding because of their short lifetime. Here a solid sample extraction, storage, and transport technique allows disconnecting production from end-user sites handling, as well as hour-long lifetimes of the agents.https://doi.org/10.1038/s42004-021-00536-9
spellingShingle Andrea Capozzi
Jan Kilund
Magnus Karlsson
Saket Patel
Arthur Cesar Pinon
François Vibert
Olivier Ouari
Mathilde H. Lerche
Jan Henrik Ardenkjær-Larsen
Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
Communications Chemistry
title Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
title_full Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
title_fullStr Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
title_full_unstemmed Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
title_short Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization
title_sort metabolic contrast agents produced from transported solid 13c glucose hyperpolarized via dynamic nuclear polarization
url https://doi.org/10.1038/s42004-021-00536-9
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