Closed-Loop Identification of Baroreflex Properties in the Frequency Domain
The arterial baroreflex system plays a key role in maintaining the homeostasis of arterial pressure (AP). Changes in AP affect autonomic nervous activities through the baroreflex neural arc, whereas changes in the autonomic nervous activities, in turn, alter AP through the baroreflex peripheral arc....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.694512/full |
| _version_ | 1818584702016028672 |
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| author | Toru Kawada Keita Saku Tadayoshi Miyamoto |
| author_facet | Toru Kawada Keita Saku Tadayoshi Miyamoto |
| author_sort | Toru Kawada |
| collection | DOAJ |
| description | The arterial baroreflex system plays a key role in maintaining the homeostasis of arterial pressure (AP). Changes in AP affect autonomic nervous activities through the baroreflex neural arc, whereas changes in the autonomic nervous activities, in turn, alter AP through the baroreflex peripheral arc. This closed-loop negative feedback operation makes it difficult to identify open-loop dynamic characteristics of the neural and peripheral arcs. Regarding sympathetic AP controls, we examined the applicability of a nonparametric frequency-domain closed-loop identification method to the carotid sinus baroreflex system in anesthetized rabbits. This article compares the results of an open-loop analysis applied to open-loop data, an open-loop analysis erroneously applied to closed-loop data, and a closed-loop analysis applied to closed-loop data. To facilitate the understanding of the analytical method, sample data files and sample analytical codes were provided. In the closed-loop identification, properties of the unknown central noise that modulated the sympathetic nerve activity and the unknown peripheral noise that fluctuated AP affected the accuracy of the estimation results. A priori knowledge about the open-loop dynamic characteristics of the arterial baroreflex system may be used to advance the assessment of baroreflex function under closed-loop conditions in the future. |
| first_indexed | 2024-12-16T08:25:22Z |
| format | Article |
| id | doaj.art-0223f0611beb48febf0ff7cd77725404 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-16T08:25:22Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0223f0611beb48febf0ff7cd777254042022-12-21T22:38:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-08-011510.3389/fnins.2021.694512694512Closed-Loop Identification of Baroreflex Properties in the Frequency DomainToru Kawada0Keita Saku1Tadayoshi Miyamoto2Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, JapanDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, JapanDepartment of Sport and Health Sciences, Faculty of Sport and Health Sciences, Osaka Sangyo University, Osaka, JapanThe arterial baroreflex system plays a key role in maintaining the homeostasis of arterial pressure (AP). Changes in AP affect autonomic nervous activities through the baroreflex neural arc, whereas changes in the autonomic nervous activities, in turn, alter AP through the baroreflex peripheral arc. This closed-loop negative feedback operation makes it difficult to identify open-loop dynamic characteristics of the neural and peripheral arcs. Regarding sympathetic AP controls, we examined the applicability of a nonparametric frequency-domain closed-loop identification method to the carotid sinus baroreflex system in anesthetized rabbits. This article compares the results of an open-loop analysis applied to open-loop data, an open-loop analysis erroneously applied to closed-loop data, and a closed-loop analysis applied to closed-loop data. To facilitate the understanding of the analytical method, sample data files and sample analytical codes were provided. In the closed-loop identification, properties of the unknown central noise that modulated the sympathetic nerve activity and the unknown peripheral noise that fluctuated AP affected the accuracy of the estimation results. A priori knowledge about the open-loop dynamic characteristics of the arterial baroreflex system may be used to advance the assessment of baroreflex function under closed-loop conditions in the future.https://www.frontiersin.org/articles/10.3389/fnins.2021.694512/fullbaroreflexwhite noisesympathetic nerve activityarterial pressuretransfer function |
| spellingShingle | Toru Kawada Keita Saku Tadayoshi Miyamoto Closed-Loop Identification of Baroreflex Properties in the Frequency Domain Frontiers in Neuroscience baroreflex white noise sympathetic nerve activity arterial pressure transfer function |
| title | Closed-Loop Identification of Baroreflex Properties in the Frequency Domain |
| title_full | Closed-Loop Identification of Baroreflex Properties in the Frequency Domain |
| title_fullStr | Closed-Loop Identification of Baroreflex Properties in the Frequency Domain |
| title_full_unstemmed | Closed-Loop Identification of Baroreflex Properties in the Frequency Domain |
| title_short | Closed-Loop Identification of Baroreflex Properties in the Frequency Domain |
| title_sort | closed loop identification of baroreflex properties in the frequency domain |
| topic | baroreflex white noise sympathetic nerve activity arterial pressure transfer function |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.694512/full |
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