Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials
Background and aims: Several randomized controlled trials (RCTs) have shown that almonds can improve oxidative stress indices, but the results are controversial. Therefore, the goal of this research was to carry out a systematic review and meta-analysis of all RCTs that evaluated the effect of almon...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229923000225 |
| _version_ | 1797858790349996032 |
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| author | Bingfeng Luo Walid Theib Mohammad Abduladheem Turki Jalil Marwan Mahmood Saleh Muataz Mohammed Al-Taee Mohammad Y. Alshahrani Naseer Mihdi Mohammed Ammar Heydani |
| author_facet | Bingfeng Luo Walid Theib Mohammad Abduladheem Turki Jalil Marwan Mahmood Saleh Muataz Mohammed Al-Taee Mohammad Y. Alshahrani Naseer Mihdi Mohammed Ammar Heydani |
| author_sort | Bingfeng Luo |
| collection | DOAJ |
| description | Background and aims: Several randomized controlled trials (RCTs) have shown that almonds can improve oxidative stress indices, but the results are controversial. Therefore, the goal of this research was to carry out a systematic review and meta-analysis of all RCTs that evaluated the effect of almonds on selected oxidative stress indices. Methods: A systematic search was conducted up to April 2022 on PubMed, Scopus, Web of Science, and Google Scholar. We have selected the studies that investigated the effects of almonds on malondialdehyde (MDA), and oxidized low-density lipoprotein (Ox-LDL) levels in adults. Data were pooled by using the random-effects model. The risk of bias in individual studies was assessed using the Cochrane Collaboration risk of bias tool. Results: Seven RCTs involving 424 participants were analyzed. The results indicated that almond intake led to a significant decrease in MDA levels (WMD: − 6.63 nmol/ml; 95 % CI: − 8.72 to − 4.54; P < 0.001). However, no significant effect was observed on Ox-LDL (Hedges’ g: − 0.12; 95 % CI: − 0.34 to 0.10; P = 0.28). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias. Conclusion: The present meta-analysis suggests that almond intake can improve MDA levels and might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults. There is a need for more studies with larger groups to better estimate this effect. |
| first_indexed | 2024-04-09T21:20:08Z |
| format | Article |
| id | doaj.art-0224b5568c3849f9a1d69c0ad25b065a |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-04-09T21:20:08Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-0224b5568c3849f9a1d69c0ad25b065a2023-03-28T06:45:26ZengElsevierComplementary Therapies in Medicine0965-22992023-05-0173102935Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trialsBingfeng Luo0Walid Theib Mohammad1Abduladheem Turki Jalil2Marwan Mahmood Saleh3Muataz Mohammed Al-Taee4Mohammad Y. Alshahrani5Naseer Mihdi Mohammed6Ammar Heydani7Department of Pharmacy, The First People’s Hospital of Lanzhou, Lanzhou 730050, China; Corresponding authors.Al-Hussein Bin Talal University, Princess Aisha Bint Al Hussein College for Nursing and Health Sciences, Princess Aisha Nursing College, JordanMedical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, Iraq; Corresponding authors.Department of Biophysics, College of Applied Sciences, University of Anbar, Iraq; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, IraqDepartment of Medical Laboratories Technology, AL-Nisour University College, Baghdad, IraqDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha 9088, Saudi ArabiaDepartment of Pharmacy, Mazaya University College, Dhi Qar, IraqIndipendent Researcher, Tehran, Islamic Republic of Iran; Corresponding authors.Background and aims: Several randomized controlled trials (RCTs) have shown that almonds can improve oxidative stress indices, but the results are controversial. Therefore, the goal of this research was to carry out a systematic review and meta-analysis of all RCTs that evaluated the effect of almonds on selected oxidative stress indices. Methods: A systematic search was conducted up to April 2022 on PubMed, Scopus, Web of Science, and Google Scholar. We have selected the studies that investigated the effects of almonds on malondialdehyde (MDA), and oxidized low-density lipoprotein (Ox-LDL) levels in adults. Data were pooled by using the random-effects model. The risk of bias in individual studies was assessed using the Cochrane Collaboration risk of bias tool. Results: Seven RCTs involving 424 participants were analyzed. The results indicated that almond intake led to a significant decrease in MDA levels (WMD: − 6.63 nmol/ml; 95 % CI: − 8.72 to − 4.54; P < 0.001). However, no significant effect was observed on Ox-LDL (Hedges’ g: − 0.12; 95 % CI: − 0.34 to 0.10; P = 0.28). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias. Conclusion: The present meta-analysis suggests that almond intake can improve MDA levels and might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults. There is a need for more studies with larger groups to better estimate this effect.http://www.sciencedirect.com/science/article/pii/S0965229923000225AlmondOxidative stressMalondialdehydeSystematic reviewMeta-analysis |
| spellingShingle | Bingfeng Luo Walid Theib Mohammad Abduladheem Turki Jalil Marwan Mahmood Saleh Muataz Mohammed Al-Taee Mohammad Y. Alshahrani Naseer Mihdi Mohammed Ammar Heydani Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials Complementary Therapies in Medicine Almond Oxidative stress Malondialdehyde Systematic review Meta-analysis |
| title | Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials |
| title_full | Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials |
| title_fullStr | Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials |
| title_full_unstemmed | Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials |
| title_short | Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials |
| title_sort | effects of almond intake on oxidative stress parameters a systematic review and meta analysis of clinical trials |
| topic | Almond Oxidative stress Malondialdehyde Systematic review Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0965229923000225 |
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