Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis
Abstract Background The effectiveness of ketogenic diet (KD) in ameliorating fatty liver has been established, although its mechanism is under investigation. Fibroblast growth factor 21 (FGF21) positively regulates obesity-associated metabolic disorders and is elevated by KD. FGF21 conventionally in...
Main Authors: | Wanrong Guo, Huanyi Cao, Yunfeng Shen, Wuguo Li, Wei Wang, Lidan Cheng, Mengyin Cai, Fen Xu |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2024-04-01
|
Series: | Nutrition & Diabetes |
Online Access: | https://doi.org/10.1038/s41387-024-00277-3 |
Similar Items
-
Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD
by: Huanyi Cao, et al.
Published: (2023-04-01) -
Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.
by: Chaofeng Yang, et al.
Published: (2012-01-01) -
Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
by: Archita Agrawal, et al.
Published: (2018-07-01) -
FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation
by: Helle Keinicke, et al.
Published: (2020-08-01) -
Exploring the impacts of ketogenic diet on reversible hepatic steatosis: initial analysis in male mice
by: Gaetan Ravaut, et al.
Published: (2024-03-01)