Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial
The effects of resistant starch at high doses have been well-characterized, but the potential prebiotic effects of resistant starch at doses comparable to oligosaccharide prebiotics have not been evaluated. A three-arm randomized, double-blind, placebo-controlled clinical trial was conducted to eval...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1582 |
| _version_ | 1797607235622273024 |
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| author | Jason R. Bush Joshua Baisley Scott V. Harding Michelle J. Alfa |
| author_facet | Jason R. Bush Joshua Baisley Scott V. Harding Michelle J. Alfa |
| author_sort | Jason R. Bush |
| collection | DOAJ |
| description | The effects of resistant starch at high doses have been well-characterized, but the potential prebiotic effects of resistant starch at doses comparable to oligosaccharide prebiotics have not been evaluated. A three-arm randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effect of 3.5 g and 7 g daily doses of Solnul<sup>™</sup> resistant potato starch (RPS) on beneficial populations of gut bacteria and stool consistency after a 4-week period. The relative abundance of <i>Bifidobacterium</i> and <i>Akkermansia</i> was determined by employing 16Sv4 sequencing of stool samples. To assess the effect of RPS on laxation and bowel movements, stools were recorded and scored using the Bristol Stool Form Scale. Participants consuming 3.5 g/day of RPS experienced significantly greater changes in Bifidobacterium and Akkermansia compared to the placebo after 4 weeks. The number of diarrhea- and constipation-associated bowel movements were both significantly lower in the 3.5 g RPS arm compared to the placebo group. Participants consuming 7 g of RPS responded similarly to those in the 3.5 g arm. Our analyses demonstrate that Solnul<sup>™</sup> RPS has a prebiotic effect when consumed for 4 weeks at the 3.5 g per day dose, stimulating increases in beneficial health-associated bacteria and reducing diarrhea- and constipation-associated bowel movements when compared to the placebo group. |
| first_indexed | 2024-03-11T05:28:21Z |
| format | Article |
| id | doaj.art-02280837bc1d450bbe61deaa7a981cb4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:28:21Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-02280837bc1d450bbe61deaa7a981cb42023-11-17T17:19:03ZengMDPI AGNutrients2072-66432023-03-01157158210.3390/nu15071582Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical TrialJason R. Bush0Joshua Baisley1Scott V. Harding2Michelle J. Alfa3MSP Starch Products Inc., Carberry, MB R0K 0H0, CanadaNutrasource Pharmaceutical and Nutraceutical Services, Guelph, ON N1G 0B4, CanadaDepartment of Biochemistry, Faculty of Science, Memorial University of Newfoundland, St. John’s, NL A1C 5S7, CanadaAlfaMed Consulting, Winnipeg, MB R2M 5M3, CanadaThe effects of resistant starch at high doses have been well-characterized, but the potential prebiotic effects of resistant starch at doses comparable to oligosaccharide prebiotics have not been evaluated. A three-arm randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effect of 3.5 g and 7 g daily doses of Solnul<sup>™</sup> resistant potato starch (RPS) on beneficial populations of gut bacteria and stool consistency after a 4-week period. The relative abundance of <i>Bifidobacterium</i> and <i>Akkermansia</i> was determined by employing 16Sv4 sequencing of stool samples. To assess the effect of RPS on laxation and bowel movements, stools were recorded and scored using the Bristol Stool Form Scale. Participants consuming 3.5 g/day of RPS experienced significantly greater changes in Bifidobacterium and Akkermansia compared to the placebo after 4 weeks. The number of diarrhea- and constipation-associated bowel movements were both significantly lower in the 3.5 g RPS arm compared to the placebo group. Participants consuming 7 g of RPS responded similarly to those in the 3.5 g arm. Our analyses demonstrate that Solnul<sup>™</sup> RPS has a prebiotic effect when consumed for 4 weeks at the 3.5 g per day dose, stimulating increases in beneficial health-associated bacteria and reducing diarrhea- and constipation-associated bowel movements when compared to the placebo group.https://www.mdpi.com/2072-6643/15/7/1582prebioticconstipationdiarrheapotatoresistant starch<i>Bifidobacterium</i> |
| spellingShingle | Jason R. Bush Joshua Baisley Scott V. Harding Michelle J. Alfa Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial Nutrients prebiotic constipation diarrhea potato resistant starch <i>Bifidobacterium</i> |
| title | Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial |
| title_full | Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial |
| title_fullStr | Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial |
| title_short | Consumption of Solnul<sup>™</sup> Resistant Potato Starch Produces a Prebiotic Effect in a Randomized, Placebo-Controlled Clinical Trial |
| title_sort | consumption of solnul sup ™ sup resistant potato starch produces a prebiotic effect in a randomized placebo controlled clinical trial |
| topic | prebiotic constipation diarrhea potato resistant starch <i>Bifidobacterium</i> |
| url | https://www.mdpi.com/2072-6643/15/7/1582 |
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