Characterization of scrotal involvement in children and adolescents with IgA vasculitis
Abstract Objective To characterize scrotal involvement in children and adolescents with IgA vasculitis. Methods A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatm...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Advances in Rheumatology |
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| Online Access: | http://link.springer.com/article/10.1186/s42358-018-0039-3 |
| _version_ | 1818110104036179968 |
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| author | Izabel M. Buscatti Henrique M. Abrão Katia Kozu Victor L. S. Marques Roberta C. Gomes Adriana M. E. Sallum Clovis A. Silva |
| author_facet | Izabel M. Buscatti Henrique M. Abrão Katia Kozu Victor L. S. Marques Roberta C. Gomes Adriana M. E. Sallum Clovis A. Silva |
| author_sort | Izabel M. Buscatti |
| collection | DOAJ |
| description | Abstract Objective To characterize scrotal involvement in children and adolescents with IgA vasculitis. Methods A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Results Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0–12) vs. 6 (1.3–13) years, p = 0.249] was similar in both groups. The frequency of elevated serum IgA was significantly lower in IgA vasculitis patients with scrotal involvement versus without this manifestation (18% vs. 57%, p = 0.017), whereas glucocorticoid (93% vs. 49%, p < 0.0001) and ranitidine use (63% vs. 30%, p = 0.003) were significantly higher in the former group. Conclusions The scrotal involvement occurred in almost one fifth of IgA vasculitis patients and was commonly evidenced as acute subtype at diagnosis. Scrotal signs/symptoms improved after a prompt use of glucocorticoid and was associated with low frequency of elevated IgA serum levels. |
| first_indexed | 2024-12-11T02:41:50Z |
| format | Article |
| id | doaj.art-02292cefc0044615a2ba9ebd561d5279 |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-11T02:41:50Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-02292cefc0044615a2ba9ebd561d52792022-12-22T01:23:33ZengBMCAdvances in Rheumatology2523-31062018-11-015811510.1186/s42358-018-0039-3Characterization of scrotal involvement in children and adolescents with IgA vasculitisIzabel M. Buscatti0Henrique M. Abrão1Katia Kozu2Victor L. S. Marques3Roberta C. Gomes4Adriana M. E. Sallum5Clovis A. Silva6Pediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloUniversidade de Santo Amaro – UNISAPediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloPediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloPediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloPediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloPediatric Rheumatology Unit, Children’s Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloAbstract Objective To characterize scrotal involvement in children and adolescents with IgA vasculitis. Methods A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Results Scrotal involvement was observed in 28/150 (19%) IgA vasculitis patients. This complication was evidenced at IgA vasculitis diagnosis in 27/28 (96%). Acute recurrent scrotal involvement was observed in 2/150 (1%) and none had chronic subtype. Further analysis of patients with scrotal involvement at first episode (n = 27) compared to those without this complication (n = 122) revealed that the median age at diagnosis [4.0 (2.0–12) vs. 6 (1.3–13) years, p = 0.249] was similar in both groups. The frequency of elevated serum IgA was significantly lower in IgA vasculitis patients with scrotal involvement versus without this manifestation (18% vs. 57%, p = 0.017), whereas glucocorticoid (93% vs. 49%, p < 0.0001) and ranitidine use (63% vs. 30%, p = 0.003) were significantly higher in the former group. Conclusions The scrotal involvement occurred in almost one fifth of IgA vasculitis patients and was commonly evidenced as acute subtype at diagnosis. Scrotal signs/symptoms improved after a prompt use of glucocorticoid and was associated with low frequency of elevated IgA serum levels.http://link.springer.com/article/10.1186/s42358-018-0039-3IgA vasculitisHenoch-Schönlein purpuraScrotal vasculitisChildrenGlucocorticoidTesticular ultrasound |
| spellingShingle | Izabel M. Buscatti Henrique M. Abrão Katia Kozu Victor L. S. Marques Roberta C. Gomes Adriana M. E. Sallum Clovis A. Silva Characterization of scrotal involvement in children and adolescents with IgA vasculitis Advances in Rheumatology IgA vasculitis Henoch-Schönlein purpura Scrotal vasculitis Children Glucocorticoid Testicular ultrasound |
| title | Characterization of scrotal involvement in children and adolescents with IgA vasculitis |
| title_full | Characterization of scrotal involvement in children and adolescents with IgA vasculitis |
| title_fullStr | Characterization of scrotal involvement in children and adolescents with IgA vasculitis |
| title_full_unstemmed | Characterization of scrotal involvement in children and adolescents with IgA vasculitis |
| title_short | Characterization of scrotal involvement in children and adolescents with IgA vasculitis |
| title_sort | characterization of scrotal involvement in children and adolescents with iga vasculitis |
| topic | IgA vasculitis Henoch-Schönlein purpura Scrotal vasculitis Children Glucocorticoid Testicular ultrasound |
| url | http://link.springer.com/article/10.1186/s42358-018-0039-3 |
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