Efficacy of Carbamazepine in treatment of bronchial asthma
Body: Settings: The real break-throw in asthma treatment is still unreachable. In many cases drugs are not effective for reaching the control state. Objectives: To investigate the efficacy of Carbamazepine in treatment of bronchial asthma. Patients and methods: A randomized, parallel 6-month trial....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763813002707 |
| _version_ | 1829479456520011776 |
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| author | Mohamed Shahat Badawy Sayed Mohamed Ismail Mohamed Abdallah Abass |
| author_facet | Mohamed Shahat Badawy Sayed Mohamed Ismail Mohamed Abdallah Abass |
| author_sort | Mohamed Shahat Badawy |
| collection | DOAJ |
| description | Body: Settings: The real break-throw in asthma treatment is still unreachable. In many cases drugs are not effective for reaching the control state. Objectives: To investigate the efficacy of Carbamazepine in treatment of bronchial asthma.
Patients and methods: A randomized, parallel 6-month trial. Hundred patients fulfilled the inclusion criteria and divided into two groups. Group (1) received Carbamazepine (600–1600 mg/day) in addition to their usual anti-asthmatic treatment and group (2) received only the usual anti-asthmatic therapy. Baseline electroencephalography (EEG) study was done for all patients. Assessment of asthma control according to GINA classification was done before, 3 and 6 months after therapy.
Results: The mean age of studied patients was (37.9 ± 9.47 and 28.6 ± 11.06), in group 1 & 2 respectively. Two cases in group 1 showed abnormal EEG and no abnormality in group 2. As regards level of asthma control, there was statistically significant difference between first visit and third visit in both groups with high value in group 1 (P value 0.001, 0.04). In comparing spirometric data of both groups at each visit it revealed statistically significant P value in all parameters (FEV1 0.001, FVC 0.003, PEF 0.01, FEF 25–75 0.001) except FEV1/FVC (P value was 0.264). The frequency of acute asthma exacerbation in both groups was (0.5 ± 0.57 and 3.2 ± 0.98) in group 1 and 2, respectively (95% CI 2.4–3.1) with highly significant P value 0.003. In the Carbamazepine group dizziness was recorded in 6 cases 12%, itching in 2 cases 4%, and increasing sleepiness in 2 cases 4%.
Conclusion: Carbamazepine is effective in treatment and in achievement of better asthma control with minimal side effect. |
| first_indexed | 2024-12-14T17:37:30Z |
| format | Article |
| id | doaj.art-022d1f5b311944269f1f5c23bab148da |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-14T17:37:30Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-022d1f5b311944269f1f5c23bab148da2022-12-21T22:52:56ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382014-01-01631152010.1016/j.ejcdt.2013.11.013Efficacy of Carbamazepine in treatment of bronchial asthmaMohamed Shahat Badawy0Sayed Mohamed Ismail1Mohamed Abdallah Abass2Chest Department, Qena Faculty of Medicine, South Valley University, EgyptChest Department, Qena Faculty of Medicine, South Valley University, EgyptNeurology Department, Qena Faculty of Medicine, South Valley University, EgyptBody: Settings: The real break-throw in asthma treatment is still unreachable. In many cases drugs are not effective for reaching the control state. Objectives: To investigate the efficacy of Carbamazepine in treatment of bronchial asthma. Patients and methods: A randomized, parallel 6-month trial. Hundred patients fulfilled the inclusion criteria and divided into two groups. Group (1) received Carbamazepine (600–1600 mg/day) in addition to their usual anti-asthmatic treatment and group (2) received only the usual anti-asthmatic therapy. Baseline electroencephalography (EEG) study was done for all patients. Assessment of asthma control according to GINA classification was done before, 3 and 6 months after therapy. Results: The mean age of studied patients was (37.9 ± 9.47 and 28.6 ± 11.06), in group 1 & 2 respectively. Two cases in group 1 showed abnormal EEG and no abnormality in group 2. As regards level of asthma control, there was statistically significant difference between first visit and third visit in both groups with high value in group 1 (P value 0.001, 0.04). In comparing spirometric data of both groups at each visit it revealed statistically significant P value in all parameters (FEV1 0.001, FVC 0.003, PEF 0.01, FEF 25–75 0.001) except FEV1/FVC (P value was 0.264). The frequency of acute asthma exacerbation in both groups was (0.5 ± 0.57 and 3.2 ± 0.98) in group 1 and 2, respectively (95% CI 2.4–3.1) with highly significant P value 0.003. In the Carbamazepine group dizziness was recorded in 6 cases 12%, itching in 2 cases 4%, and increasing sleepiness in 2 cases 4%. Conclusion: Carbamazepine is effective in treatment and in achievement of better asthma control with minimal side effect.http://www.sciencedirect.com/science/article/pii/S0422763813002707EfficacyCarbamazepineBronchial asthmaTreatment |
| spellingShingle | Mohamed Shahat Badawy Sayed Mohamed Ismail Mohamed Abdallah Abass Efficacy of Carbamazepine in treatment of bronchial asthma Egyptian Journal of Chest Disease and Tuberculosis Efficacy Carbamazepine Bronchial asthma Treatment |
| title | Efficacy of Carbamazepine in treatment of bronchial asthma |
| title_full | Efficacy of Carbamazepine in treatment of bronchial asthma |
| title_fullStr | Efficacy of Carbamazepine in treatment of bronchial asthma |
| title_full_unstemmed | Efficacy of Carbamazepine in treatment of bronchial asthma |
| title_short | Efficacy of Carbamazepine in treatment of bronchial asthma |
| title_sort | efficacy of carbamazepine in treatment of bronchial asthma |
| topic | Efficacy Carbamazepine Bronchial asthma Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S0422763813002707 |
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