Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation

Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mechanisms of circular RNA and SUMOylation in the development of ICC remain poorly understood. Methods Circular RNA hsa_circ_0001681 (termed Circ-RAPGEF5 hereafte...

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Bibliographic Details
Main Authors: Junhao Zheng, Yali Wang, Liye Tao, Jingwei Cai, Zefeng Shen, Yang Liu, Haoyu Pan, Shihao Li, Yeling Ruan, Tianyi Chen, Zhengtao Ye, Kainan Lin, Yin Sun, Junjie Xu, Xiao Liang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Intrahepatic cholangiocarcinoma
Circ-RAPGEF5
SAE1
SUMOylation
AKT
Online Access:https://doi.org/10.1186/s13046-023-02813-y

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