Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth
Wnt/β-catenin signalling is frequently hyperactivated in colorectal carcinoma (CRC). Here the authors show that Gαi2 inhibits this signalling pathway by promoting the condensation of conductin/axin2 and β-catenin degradation, and consequently suppresses CRC growth.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28286-9 |
| _version_ | 1798022550095134720 |
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| author | Cezanne Miete Gonzalo P. Solis Alexey Koval Martina Brückner Vladimir L. Katanaev Jürgen Behrens Dominic B. Bernkopf |
| author_facet | Cezanne Miete Gonzalo P. Solis Alexey Koval Martina Brückner Vladimir L. Katanaev Jürgen Behrens Dominic B. Bernkopf |
| author_sort | Cezanne Miete |
| collection | DOAJ |
| description | Wnt/β-catenin signalling is frequently hyperactivated in colorectal carcinoma (CRC). Here the authors show that Gαi2 inhibits this signalling pathway by promoting the condensation of conductin/axin2 and β-catenin degradation, and consequently suppresses CRC growth. |
| first_indexed | 2024-04-11T17:31:52Z |
| format | Article |
| id | doaj.art-022e76d7e8894ba1aba6ff13a89518c1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T17:31:52Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-022e76d7e8894ba1aba6ff13a89518c12022-12-22T04:11:58ZengNature PortfolioNature Communications2041-17232022-02-0113111610.1038/s41467-022-28286-9Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growthCezanne Miete0Gonzalo P. Solis1Alexey Koval2Martina Brückner3Vladimir L. Katanaev4Jürgen Behrens5Dominic B. Bernkopf6Experimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergDepartment of Cell Physiology and Metabolism, Centre Médical Universitaire, University of GenevaDepartment of Cell Physiology and Metabolism, Centre Médical Universitaire, University of GenevaExperimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergDepartment of Cell Physiology and Metabolism, Centre Médical Universitaire, University of GenevaExperimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergExperimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-NürnbergWnt/β-catenin signalling is frequently hyperactivated in colorectal carcinoma (CRC). Here the authors show that Gαi2 inhibits this signalling pathway by promoting the condensation of conductin/axin2 and β-catenin degradation, and consequently suppresses CRC growth.https://doi.org/10.1038/s41467-022-28286-9 |
| spellingShingle | Cezanne Miete Gonzalo P. Solis Alexey Koval Martina Brückner Vladimir L. Katanaev Jürgen Behrens Dominic B. Bernkopf Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth Nature Communications |
| title | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth |
| title_full | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth |
| title_fullStr | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth |
| title_full_unstemmed | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth |
| title_short | Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth |
| title_sort | gαi2 induced conductin axin2 condensates inhibit wnt β catenin signaling and suppress cancer growth |
| url | https://doi.org/10.1038/s41467-022-28286-9 |
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