Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1–2

Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1–2

Abstract Background Many transcription factors (TFs), such as multi zinc-finger (ZF) TFs, have multiple DNA binding domains (DBDs), and deciphering the DNA binding motifs of individual DBDs is a major challenge. One example of such a TF is CCCTC-binding factor (CTCF), a TF with eleven ZFs that plays...

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Bibliographic Details
Main Authors: Irene M. Kaplow, Abhimanyu Banerjee, Chuan Sheng Foo
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Genomics
Subjects:
Mutated transcription factor
CTCF
Zinc finger
Motif
Deep neural network
Binding strength
Online Access:https://doi.org/10.1186/s12864-022-08486-9

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