Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study
Fragility fractures (FFxs), which are a common musculoskeletal injury in older adults, is associated with an increased frequency of falls. Both FFxs and falls may result from drugs, habits, and co-occurring diseases. We aimed to evaluate the effects of various diseases on the risk of FFx. This retro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/15/3225 |
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| author | Garu A Shozo Yano Abdullah Md Sheik Aorigele Yu Kenta Okuyama Miwako Takeda Kunie Kohno Masayuki Yamasaki Minoru Isomura Toru Nabika Atsushi Nagai |
| author_facet | Garu A Shozo Yano Abdullah Md Sheik Aorigele Yu Kenta Okuyama Miwako Takeda Kunie Kohno Masayuki Yamasaki Minoru Isomura Toru Nabika Atsushi Nagai |
| author_sort | Garu A |
| collection | DOAJ |
| description | Fragility fractures (FFxs), which are a common musculoskeletal injury in older adults, is associated with an increased frequency of falls. Both FFxs and falls may result from drugs, habits, and co-occurring diseases. We aimed to evaluate the effects of various diseases on the risk of FFx. This retrospective study included 1420 individuals aged ≥60 years. We evaluated the history of clinical FFx and diseases using a detailed questionnaire and a health examination. The risk of comorbidities was assessed using the Age-Adjusted Charlson Comorbidity (AAC) Index. We performed binary logistic regression analysis to determine the risk of FFx and falls after adjusting for covariates. In elderly men, the incidence of FFx positively correlated with rheumatoid arthritis and parent’s hip fracture. For elderly women, the incidence of FFx positively correlated with rheumatoid arthritis and antihypertensive drugs but was inversely associated with dyslipidemia and antilipidemic drugs. The FFX risk of older adults with an AAC Index ≥6 was higher than those with an AAC Index of 1–3. In addition, the AAC Index and falls were independently and strongly associated with a higher risk of FFx. Taken together, multimorbidity increases the risk of clinical FFx independent of falls in the community-dwelling elderly population. |
| first_indexed | 2024-03-10T09:13:36Z |
| format | Article |
| id | doaj.art-023079f7438a42329f71443e718a0adc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:13:36Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-023079f7438a42329f71443e718a0adc2023-11-22T05:47:40ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015322510.3390/jcm10153225Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE StudyGaru A0Shozo Yano1Abdullah Md Sheik2Aorigele Yu3Kenta Okuyama4Miwako Takeda5Kunie Kohno6Masayuki Yamasaki7Minoru Isomura8Toru Nabika9Atsushi Nagai10Department of Neurology, Shimane University Faculty of Medicine, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanDepartment of Laboratory Medicine, Shimane University Faculty of Medicine, Izumo 693-8501, JapanDepartment of Orthopaedic Surgery, Shimane University Faculty of Medicine, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanCenter for Community-Based Healthcare Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo 693-8501, JapanDepartment of Neurology, Shimane University Faculty of Medicine, Izumo 693-8501, JapanFragility fractures (FFxs), which are a common musculoskeletal injury in older adults, is associated with an increased frequency of falls. Both FFxs and falls may result from drugs, habits, and co-occurring diseases. We aimed to evaluate the effects of various diseases on the risk of FFx. This retrospective study included 1420 individuals aged ≥60 years. We evaluated the history of clinical FFx and diseases using a detailed questionnaire and a health examination. The risk of comorbidities was assessed using the Age-Adjusted Charlson Comorbidity (AAC) Index. We performed binary logistic regression analysis to determine the risk of FFx and falls after adjusting for covariates. In elderly men, the incidence of FFx positively correlated with rheumatoid arthritis and parent’s hip fracture. For elderly women, the incidence of FFx positively correlated with rheumatoid arthritis and antihypertensive drugs but was inversely associated with dyslipidemia and antilipidemic drugs. The FFX risk of older adults with an AAC Index ≥6 was higher than those with an AAC Index of 1–3. In addition, the AAC Index and falls were independently and strongly associated with a higher risk of FFx. Taken together, multimorbidity increases the risk of clinical FFx independent of falls in the community-dwelling elderly population.https://www.mdpi.com/2077-0383/10/15/3225fracture riskfallelderlymultimorbiditylogistic regression analysis |
| spellingShingle | Garu A Shozo Yano Abdullah Md Sheik Aorigele Yu Kenta Okuyama Miwako Takeda Kunie Kohno Masayuki Yamasaki Minoru Isomura Toru Nabika Atsushi Nagai Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study Journal of Clinical Medicine fracture risk fall elderly multimorbidity logistic regression analysis |
| title | Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study |
| title_full | Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study |
| title_fullStr | Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study |
| title_full_unstemmed | Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study |
| title_short | Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study |
| title_sort | effect of multimorbidity on fragility fractures in community dwelling older adults shimane cohre study |
| topic | fracture risk fall elderly multimorbidity logistic regression analysis |
| url | https://www.mdpi.com/2077-0383/10/15/3225 |
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