Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake
To study the occurrence of surgery-related muscle loss (SRML) and its association with in-hospital nutritional intake, we conducted a prospective observational cohort study including patients who underwent pancreatic surgery because of (suspected) malignant diseases. Muscle diameter was measured by...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/969 |
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| author | Rianne N. M. Hogenbirk Judith E. K. R. Hentzen Willemijn Y. van der Plas Marjo J. E. Campmans-Kuijpers Schelto Kruijff Joost M. Klaase |
| author_facet | Rianne N. M. Hogenbirk Judith E. K. R. Hentzen Willemijn Y. van der Plas Marjo J. E. Campmans-Kuijpers Schelto Kruijff Joost M. Klaase |
| author_sort | Rianne N. M. Hogenbirk |
| collection | DOAJ |
| description | To study the occurrence of surgery-related muscle loss (SRML) and its association with in-hospital nutritional intake, we conducted a prospective observational cohort study including patients who underwent pancreatic surgery because of (suspected) malignant diseases. Muscle diameter was measured by using bedside ultrasound 1 day prior to surgery and 7 days postoperatively. Clinically relevant SRML was defined as ≥10% muscle diameter loss in minimally one arm and leg muscle within 1 week after surgery. Protein and caloric intake was measured by nutritional diaries. The primary endpoint included the number of patients with SRML. Secondary endpoints included the association between SRML and postoperative nutritional intake. Of the 63 included patients (60.3% men; age 67.1 ± 10.2 years), a total of 24 patients (38.1%) showed SRML. No differences were observed in severe complication rate or length of hospital stay between patients with and without SRML. During the first postoperative week, patients with clinically relevant SRML experienced more days without any nutritional intake compared with the non-SRML group (1 [0–4] versus 0 [0–1] days, <i>p</i> = 0.007). Significantly lower nutritional intake was found in the SRML group at postoperative days 2, 3 and 5 (<i>p</i> < 0.05). Since this study shows that SRML occurred in 38.1% of the patients and most of the patients failed to reach internationally set nutritional goals, it is suggested that more awareness concerning direct postoperative nutritional intake is needed in our surgical community. |
| first_indexed | 2024-03-11T09:49:42Z |
| format | Article |
| id | doaj.art-02313a0271194e37b7e4802981dc6d72 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:49:42Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-02313a0271194e37b7e4802981dc6d722023-11-16T16:19:49ZengMDPI AGCancers2072-66942023-02-0115396910.3390/cancers15030969Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional IntakeRianne N. M. Hogenbirk0Judith E. K. R. Hentzen1Willemijn Y. van der Plas2Marjo J. E. Campmans-Kuijpers3Schelto Kruijff4Joost M. Klaase5Department of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Surgery, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsTo study the occurrence of surgery-related muscle loss (SRML) and its association with in-hospital nutritional intake, we conducted a prospective observational cohort study including patients who underwent pancreatic surgery because of (suspected) malignant diseases. Muscle diameter was measured by using bedside ultrasound 1 day prior to surgery and 7 days postoperatively. Clinically relevant SRML was defined as ≥10% muscle diameter loss in minimally one arm and leg muscle within 1 week after surgery. Protein and caloric intake was measured by nutritional diaries. The primary endpoint included the number of patients with SRML. Secondary endpoints included the association between SRML and postoperative nutritional intake. Of the 63 included patients (60.3% men; age 67.1 ± 10.2 years), a total of 24 patients (38.1%) showed SRML. No differences were observed in severe complication rate or length of hospital stay between patients with and without SRML. During the first postoperative week, patients with clinically relevant SRML experienced more days without any nutritional intake compared with the non-SRML group (1 [0–4] versus 0 [0–1] days, <i>p</i> = 0.007). Significantly lower nutritional intake was found in the SRML group at postoperative days 2, 3 and 5 (<i>p</i> < 0.05). Since this study shows that SRML occurred in 38.1% of the patients and most of the patients failed to reach internationally set nutritional goals, it is suggested that more awareness concerning direct postoperative nutritional intake is needed in our surgical community.https://www.mdpi.com/2072-6694/15/3/969surgery-related muscle lossmuscle wastingultrasoundPOCUSpancreatic surgerypancreatic cancer |
| spellingShingle | Rianne N. M. Hogenbirk Judith E. K. R. Hentzen Willemijn Y. van der Plas Marjo J. E. Campmans-Kuijpers Schelto Kruijff Joost M. Klaase Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake Cancers surgery-related muscle loss muscle wasting ultrasound POCUS pancreatic surgery pancreatic cancer |
| title | Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake |
| title_full | Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake |
| title_fullStr | Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake |
| title_full_unstemmed | Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake |
| title_short | Surgery-Related Muscle Loss after Pancreatic Resection and Its Association with Postoperative Nutritional Intake |
| title_sort | surgery related muscle loss after pancreatic resection and its association with postoperative nutritional intake |
| topic | surgery-related muscle loss muscle wasting ultrasound POCUS pancreatic surgery pancreatic cancer |
| url | https://www.mdpi.com/2072-6694/15/3/969 |
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